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HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway 期刊论文

编号：

71ea6d3b-940d-493d-b4a9-3d21fb6005ff
作者：

Zhang, Qianqian(张茜茜)#^[1,2,3]Wang, Yang(汪杨)^[1]Zhai, Naicui(翟乃翠)^[1]Song, Hongxiao^[1];Li, Haijun(李海军)^[1]Yang, Yang^[1];Li, Tianyang^[1];Guo, Xiaolin^[2];Chi, Baorong^[2];Niu, Junqi(牛俊奇)^[2]Crispe, Ian Nicholas^[1,4];Su, Lishan^[1,5];Tu, Zhengkun(涂正坤)*^[1,2]
语种：

英文
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2016 年 6 卷 ; OCT 27
收录：
摘要：

Hepatitis C virus (HCV) establishes persistent infection in most infected patients, and eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some patients. Monocytes and macrophages provide the first line of defense against pathogens, but their roles in HCV infection remains unclear. We have reported that HCV core protein (HCVc) manipulates human blood-derived dendritic cell development. In the present study, we tested whether HCVc affects human blood-derived monocyte differentiating into macrophages. Results showed that HCVc inhibits monocyte differentiation to either M1 or M2 macrophages through TLR2, associated with impaired STATs signaling pathway. Moreover, HCVc inhibits phagocytosis activity of M1 and M2 macrophages, M1 macrophage-induced autologous and allogeneic CD4(+) T cell activation, but promotes M2 macrophage-induced autologous and allogeneic CD4(+) T cell activation. In conclusion, HCVc inhibits monocyte-derived macrophage polarization via TLR2 signaling, leading to dysfunctions of both M1 and M2 macrophages in chronic HCV infected patients. This may contribute to the mechanism of HCV persistent infection, and suggest that blockade of HCVc might be a novel therapeutic approach to treating HCV infection.
推荐引用方式
GB/T 7714：

Zhang Qianqian,Wang Yang,Zhai Naicui, et al. HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway [J].SCIENTIFIC REPORTS,2016,6.
APA：

Zhang Qianqian,Wang Yang,Zhai Naicui,Song Hongxiao,&Tu Zhengkun.(2016).HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway .SCIENTIFIC REPORTS,6.
MLA：

Zhang Qianqian, et al. "HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway" .SCIENTIFIC REPORTS 6(2016).
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