Objectives: This study was to determine the association of the polymorphism in SLC30A8 (rs13266634), CDKN2A/2B (rs10811661), HHEX (rs1111875) or TCF7L2 (rs7903146) with T2DM in Han population in Northeast part of China. Methods: Ligase detection reaction (LDR) technology was utilized to test the genotype in the four target genes in 513 cases of T2DM patients and 307 normal volunteers. Results: It was shown that there was a significant association of SNPs in CDKN2A/2B (rs10811661) or TCF7L2 (rs7903146) (P=0.0024 and 0.0007 respectively), but not in SNPs of SLC30A8 (rs13266634) and HHEX (rs1111875) with T2DM. And there was significant difference in HbA1c, FINS, HOMA-IR, and HOMA-beta among the genotypes (TT, CT and CC) of CDKN2A/2B (rs10811661) (P=0.035, 0.022, 0.002 and 0.023 respectively). And the significant difference was also indicated in FPG, HbA1c, HOMA-IR, and HOMA-a among the three genotypes (TT, CT and CC) of SLC30A8 (rs13266634) (P=0.004, 0.005, 0.024 and 0.016 respectively). Conclusion: The present study revealed an association of CDKN2A/2B (rs10811661) and TCF7L2 (rs7903146) with type 2 diabetes in the Han population in the Northeast part of China, and there was also an association of SLC30A8 (rs13266634) and above-mentioned two SNPs with the insulin resistance in type 2 diabetes.
[1]Jilin Univ, Hosp 2, Dept Endocrinol, Changchun 130000, Peoples R China.
[2]Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130000, Peoples R China.
(8.0+极速模式)