Background: Controversy remains regarding percutaneous vertebroplasty (PVP) and kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) and the effect of age on outcomes in elderly patients has rarely been investigated. Aim: To compare therapeutic effects between PVP and PKP for aged patients stratified by different ages. Methods: A Total of 387 patients between January 2010 and January 2014 were reviewed. They were divided into 3 groups according to age: 60-69 (A: PVP, n = 61; PKP, n = 58), 70-79 (B: PVP, n = 103; PKP, n = 105), and 80-91 (C: PVP, n = 31; PKP, n = 28). Outcomes included vertebral body height, kyphotic angle, visual analog scale (VAS), Oswestry disability index (ODI), and complications after 24 months of follow up. Results: Compared with preoperation, vertebral body height was significantly increase but kyphotic angles, VAS, and ODI were decreased postoperatively in the two groups. However, no differences were observed between PVP and PKP groups. Similarly, there were no significant differences in parameters among A, B and C groups, postoperatively, nor between PVP and PKP according to age classification. Cement leakage and adjacent vertebral fractures, respectively, occurred in 22 (11.28%) and 20 (10.42%) patients in PVP and PKP groups but was not significant among A, B and C in PVP and PKP groups as well as between PVP and PKP in groups A, B and C. Conclusion: Both PVP and PKP may be effective and safe for OVCFs, regardless of age.