Objective: To explore the application effect of early ostomy closure on the patient with necrotizing enterocolitis (NEC). Methods: From January 2012 to March 2015, 23 infants with NEC which had been performed ileostomy were treated with early ostomy closure and normal ostomy closure in the First hospital of Jilin University. These infants were divided into two groups. In control group, from January 2012 to June 2013, 11 patients were performed normal ostomy closure (3-6 months after ostomy), In experimental group, from July 2013 to March 2015, 12 patients were performed early ostomy closure (less 3 months after ostomy), clinical data were retrospectively analyzed, including the time from ostomy to ostomy closure, the mean operation time, the intraoperative bleeding, the averaged length of stay (ALS), the incidence of postoperative wound infections. Results: The time from ostomy to ostomy closure of experimental group was obviously less than that of control group [(1.49 +/- 0.64) months vs (4.43 +/- 1.23) months] (P< 0.05). There were no significant difference in the mean operation time between the two groups [(62.4 +/- 9.3) minutes vs (64.5 +/- 10.7) minutes] (P>0.05). The difference of the operative blood loss in two groups were not statistically significant [(6.2 +/- 1.6) ml vs (5.5 +/- 1.4) ml] (P>0.05). The difference of the averaged length of stay (ALS) in two groups were not statistically significant [(7.5 +/- 1.5) d vs (7.3 +/- 1.1) d] (P>0.05), and the incidence of postoperative wound infections were not different between two groups too (16.7% vs 18.2%) (P>0.05). Conclusions: The early ostomy closure did not have the negative effect for the infants with NEC. Compared with normal ostomy, early ostomy closure could restore the bowel function earlier, and could avoid Long-term dehydration and malnutrition during the waiting for ostomy closure.