Rationale:With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder.Diagnoses:The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype, fluorescence in situ hybridization, and array comparative genomic hybridization from the patient"s blood culture.Interventions:The patient was given fludarabine, cyclophosphamide and rituximab (FCR) for 6 cycles.Outcomes:After completion of 6 cycles of FCR, the computed tomography scans of the neck/chest/abdomen/pelvic showed that the patient in CR. During the 10-month follow-up, the patient"s clinical course remained uneventful.Lessons:The translocation t(14;19) identified in this patient is a recurrent translocation found in patients with chronic B-cell lymphoproliferative disorders and the 3-way translocation involving chromosomes 2, 14, and 11 may play a role as an enhancer.
[1]Jilin Univ, Hosp 1, Dept Gastroenterol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
[2]Jilin Univ, Hosp 1, Dept Resp Med, Changchun 130021, Jilin, Peoples R China.
[3]Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, 1122 NE 13th St,Suite 1400, Oklahoma City, OK 73104 USA.
[4]Univ Oklahoma, Hlth Sci Ctr, Dept Hematol, Oklahoma City, OK 73104 USA.
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