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Granulocyte Colony-Stimulating Factor Enhances Bone Marrow Mononuclear Cell Homing to the Liver in a Mouse Model of Acute Hepatic Injury 期刊论文

编号：

7f78ca65-2407-45ca-99f7-122697243ca3
作者：

Jin, ShiZhu#^[1]Meng, XiangWei(孟祥伟)*^[1]Sun, Xun(孙逊)^[2]Han, MingZi^[3];Liu, BingRong^[3];Wang, XinHong^[1]Sun, LiYing^[3];Huang, Qi^[4];Zhao, RuiBo^[4];Ban, Xiang^[4];Yu, HongYing^[3];Yu, HongWei^[5];
语种：

英文
期刊：

DIGESTIVE DISEASES AND SCIENCES ISSN：0163-2116 2010 年 55 卷 10 期 (2805 - 2813) ; OCT
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关键词：

Granulocyte colony stimulating factor Bone marrow mononuclear cell Acute liver failure Transplantation Mobilization Autologous
摘要：

Experiments have reported that granulocyte colony stimulating factor (G-CSF) can mobilize stem cells. However, few studies have examined the effect of G-CSF on bone marrow mononuclear cell (BMMC) mobilization, in particular regarding their capability to home to acutely injured liver.
The aim of this study was to evaluate the effort of G-CSF on BMMC homing to the liver following chemically-induced hepatic failure.
BMMC were isolated from mice, pre-labeled with PKH26 and infused into the mice in which hepatic injury had been induced followed by administration of G-CSF or vehicle. Livers were studied by fluorescent microscopy after transplantation of pre-labeled BMMC.
PKH26 labeled cells were found in liver tissue at 102 +/- A 10 cells/high power field in the BMMC+G-CSF group and 30 +/- A 5 cells/high power field in the BMMC group, but none in the G-CSF group and the control group (P < 0.05). In the former two groups the majority of PKH26 labeled cells colocalized with proliferative cell nuclear antigen (PCNA). The number of PCNA positive cells in the BMMC+G-CSF group was 20 +/- A 4 cells/high power field, while in the BMMC group it was 14 +/- A 2 cells/high power field, in the G-CSF group 12 +/- A 2 cells/high power field, and 8 +/- A 1 cells/high power field in the control group. Moreover, albumin expression was increased in the BMMC+G-CSF treated group (149 +/- A 7/high power field) relative to the BMMC group (48 +/- A 6/high power field), the G-CSF group (44 +/- A 5/high power field) and the vehicle group (30 +/- A 6/high power field), with the former three groups showing elevated levels as compared to vehicle control (30 +/- A 6) (P < 0.05).
Transplanted BMMC may home to injured liver, which appears to be enhanced by G-CSF administration.
推荐引用方式
GB/T 7714：

Jin Shi-Zhu,Meng Xiang-Wei,Sun Xun, et al. Granulocyte Colony-Stimulating Factor Enhances Bone Marrow Mononuclear Cell Homing to the Liver in a Mouse Model of Acute Hepatic Injury [J].DIGESTIVE DISEASES AND SCIENCES,2010,55(10):2805-2813.
APA：

Jin Shi-Zhu,Meng Xiang-Wei,Sun Xun,Han Ming-Zi,&Yu Hong-Wei.(2010).Granulocyte Colony-Stimulating Factor Enhances Bone Marrow Mononuclear Cell Homing to the Liver in a Mouse Model of Acute Hepatic Injury .DIGESTIVE DISEASES AND SCIENCES,55(10):2805-2813.
MLA：

Jin Shi-Zhu, et al. "Granulocyte Colony-Stimulating Factor Enhances Bone Marrow Mononuclear Cell Homing to the Liver in a Mouse Model of Acute Hepatic Injury" .DIGESTIVE DISEASES AND SCIENCES 55,10(2010):2805-2813.
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