Gastric cancer is a common type of cancer worldwide, and has a poor prognosis, in part due to the low rates of early diagnosis and the limited treatment methods available. Apolipoprotein E (ApoE) is involved in exogenous cholesterol transport and may be important in enabling tumor cells to fulfill their high cholesterol requirements. A number of reports have indicated that ApoE affects the development and prognosis of gastric cancer. Therefore, the aim of the present study was to investigate the genes and transcription factors that interact with ApoE during the development of gastric cancer. Using gene expression profiling, the BioGRID database and the transcriptional regulatory element database, gene expression and regulatory networks in gastric cancer tissues and adjacent normal tissues were analyzed. The data demonstrated that eight genes associated with ApoE were differentially expressed, with six of these upregulated and two downregulated. Functionally, these genes were involved in the JAK-STAT cascade, acute-phase response, acute inflammatory response, and the steroid hormone response. Among these ApoE-associated genes, expression of the signal transducer and activator of transcription 2 (STAT2) and STAT3 transcription factors was upregulated. To the best of our knowledge, this is the first study to demonstrate the network of ApoE-related genes and transcription factors in gastric cancer. Additional studies are required in order to confirm these data and to translate the results into the identification of clinical biomarkers and novel treatment strategies for gastric cancer.
[1]Jilin Univ, Hosp 1, Ctr Canc, Changchun 130021, Jilin, Peoples R China.
[2]Jilin Univ, Basic Med Coll, Dept Pathogenobiol, Changchun 130021, Jilin, Peoples R China.
[3]Chinese Acad Med Sci, Peking Union Med Coll, Dept Thorac Surg Oncol, Inst Canc, Beijing 100021, Peoples R China.
[4]Qingdao Univ, Affiliated Hosp, Dept Urol, Qingdao 266000, Shandong, Peoples R China.
(8.0+极速模式)