首页 / 院系成果 / 成果详情页

Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway 期刊论文

编号：

80baf195-5219-48e8-b8f2-0dee2a72707f
作者：

Yang, Hui#^[1,2]Sun, Wanqing^[2,3];Quan, Nanhu(全南虎)^[2,3]Wang, Lin(王琳)^[2,3]Chu, Dongyang^[2];Cates, Courtney^[2];Liu, Quan(刘全)^[3]Zheng, Yang(郑杨)^[3]Li, Ji*^[2]
语种：

English
期刊：

BIOCHEMICAL PHARMACOLOGY ISSN：0006-2952 2016 年 108 卷 (47 - 57) ; MAY 15
收录：
关键词：

Myocardial infarction Notch1 AMPK LKB1 Cardioprotection
摘要：

AMP-activated protein kinase (AMPK) signaling pathway plays a pivotal role in intracellular adaptation to energy stress during myocardial ischemia. Notch1 signaling in the adult myocardium is also activated in response to ischemic stress. However, the relationship between Notch1 and AMPK signaling pathways during ischemia remains unclear. We hypothesize that Notch1 as an adaptive signaling pathway protects the heart from ischemic injury via modulating the cardioprotective AMPK signaling pathway. C57BL/6J mice were subjected to an in vivo ligation of left anterior descending coronary artery and the hearts from C57BL/6J mice were subjected to an ex vivo globe ischemia and reperfusion in the Langendorff perfusion system. The Notch1 signaling was activated during myocardial ischemia. A Notch1 gamma-secretase inhibitor, dibenzazepine (DBZ), was intraperitoneally injected into mice to inhibit Notch1 signaling pathway by ischemia. The inhibition of Notch1 signaling by DBZ significantly augmented cardiac dysfunctions caused by myocardial infarction. Intriguingly, DBZ treatment also significantly blunted the activation of AMPK signaling pathway. The immunoprecipitation experiments demonstrated that an interaction between Notch1 and liver kinase betal (LKB1) modulated AMPK activation during myocardial ischemia. Furthermore, a ligand of Notch1 jagged1 can significantly reduce cardiac damage caused by ischemia via activation of AMPK signaling pathway and modulation of glucose oxidation and fatty acid oxidation during ischemia and reperfusion. But jagged1 did not have any cardioprotections on AMPK kinase dead transgenic hearts. Taken together, the results indicate that the cardioprotective effect of Notch1 against ischemic damage is mediated by AMPK signaling via an interaction with upstream LKB1. (C) 2016 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Yang Hui,Sun Wanqing,Quan Nanhu, et al. Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway [J].BIOCHEMICAL PHARMACOLOGY,2016,108:47-57.
APA：

Yang Hui,Sun Wanqing,Quan Nanhu,Wang Lin,&Li Ji.(2016).Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway .BIOCHEMICAL PHARMACOLOGY,108:47-57.
MLA：

Yang Hui, et al. "Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway" .BIOCHEMICAL PHARMACOLOGY 108(2016):47-57.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：46  下载次数：0

分享到：

浏览次数：46

下载次数：0

打印次数：0