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520 in Invasive Pituitary Tumors 期刊论文

编号：

82114718-5d80-4a51-9137-ec65d4cb38d5
作者：

Wang, Heyuan(王贺元)#^[2,4]Wang, Guixia(王桂侠)^[2]Gao, Yufei^[1];Zhao, Conghai^[1];Li, Xiaoping(李小平)^[5]Zhang, Fuqiang^[6];Jiang, Chunyan^[7,8];Wu, Bing(吴冰)*^[1,3]
语种：

English
期刊：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ISSN：1015-8987 2018 年 48 卷 3 期 (1291 - 1303)
收录：
关键词：

Lnc-SNHG1 TGFBR2 RAB11A Wnt/beta-catenin SMAD3 Pituitary tumor
摘要：

Background/Aims: Long noncoding RNAs (IncRNAs) are critical regulators in various diseases including human cancer and could function as competing endogenous RNAs (ceRNAs) to regulate microRNAs (miRNAs). Methods: Quantitative real-time PCR (qRT-PCR) was used to analyze the expression of Inc-SNHG1 and miR-302/372/373/520 in pituitary tumor tissues and cell lines. Cell proliferation was investigated using MTT and cell count assays. The mechanisms by which Inc-SNHG1 affects pituitary tumor progression were investigated using Western blot assays, transwell migration assays, immunohistochemistry, immunofluorescence, luciferase reporter assays, tumor xenografts, and flow cytometry. Results: We found that Inc-SNHG1 was overexpressed in invasive pituitary tumor tissues and cell lines. Ectopic expression of Inc-SNHG1 promoted cell proliferation, migration, and invasion, as well as the epithelial-mesenchymal transition (EMT), by affecting the cell cycle and cell apoptosis in vitro and tumor growth in vivo. Further study indicated that overexpression of Inc-SNHG1 markedly inhibited the expression of miR-302/372/373/520 (miRNA-pool) which is down-regulated in invasive pituitary tumor cells. Moreover, overexpression of Inc-SNHG1 significantly promoted the expression of TGFBR2 and RAB11A, the direct targets of miR-302/372/373/520. Finally, Inc-SNHG1 activates the TGFBR2/SMAD3 and RAB11A/Wnt/beta-catenin pathways in pituitary tumor cells via sponging miR-302/372/373/520. Conclusions: Our data suggest that Inc-SNHG1 promotes the progression of pituitary tumors and is a potential therapeutic target for invasive pituitary tumor. (C) 2018 The Author(s) Published by S Karger AG, Basel
推荐引用方式
GB/T 7714：

Wang Heyuan,Wang Guixia,Gao Yufei, et al. Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/beta-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors [J].CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2018,48(3):1291-1303.
APA：

Wang Heyuan,Wang Guixia,Gao Yufei,Zhao Conghai,&Wu Bing.(2018).Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/beta-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,48(3):1291-1303.
MLA：

Wang Heyuan, et al. "Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/beta-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors" .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 48,3(2018):1291-1303.
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