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Identification of Driver Genes and Key Pathways of Pediatric Brain Tumors and Comparison of Molecular Pathogenesis Based on Pathologic Types 期刊论文

编号：

848685d8-c7f4-4bca-8c41-293816f421b6
作者：

Zhong, Sheng#^[1,3]Wu, Bo^[3];Han, Yujuan^[3];Cao, Yingshu^[3];Yang, Liu^[4];Luo, Sean X.^[5];Chen, Yong^[1];Zhang, Huimao(张惠茅)^[2]Zhao, Gang(赵刚)*^[1]
语种：

英文
期刊：

WORLD NEUROSURGERY ISSN：1878-8750 2017 年 107 卷 (990 - 1000) ; NOV
收录：
关键词：

Bioinformatics Brain science Glioma Medulloblastoma Pediatric brain tumor Prognosis
摘要：

OBJECTIVE: This study is to identify pediatric brain tumors (PBT) driver genes and key pathways to detect the expression of the driver genes and also to clarify the relationship between patients" prognosis and expression of driver genes.
METHODS: The gene expression profile of GSE50161 was analyzed to identify the differentially expressed genes (DEGs) between tumor tissue and the normal tissue. Gene ontology, Kyoto Encyclopedia of Genes and Genomes analysis, and protein-protein interaction network analysis were conducted to identify the enrichment functions, pathways, and hub genes. After hub genes were identified, quantitative reverse transcription polymerase chain reaction was used to confirm the differential expression of these hub genes. Survival data of 325 patients" were analyzed to clarify the relationship between prognosis and expression levels of the mutual hub genes.
RESULTS: Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis showed that there were 13 common functions and 3 common pathways which were upregulated or downregulated among the 4 groups. Mutual hub genes were somatostatin (SST), glutamate decarboxylase 2 (GAD2), and single copy human parvalbumin gene (PVALB). The expression of SST, GAD2, and PVALB in glioma cells significantly decreased compared with normal glial cells (P < 0.05). In addition, survival analysis showed a favorable progression-free and overall survival in patients with glioma with SST, GAD2, and PVALB high expression (P < 0.05).
CONCLUSIONS: SST, GAD2, and PVALB significantly decrease in glioma cells compared with normal glial cells. Survival analysis suggests that patients with high-expressed SST, GAD2, and PVALB have a longer overall and progression-free survival. The differential expressed genes identified in this study provide novel targets for diagnosis and treatment.
推荐引用方式
GB/T 7714：

Zhong Sheng,Wu Bo,Han Yujuan, et al. Identification of Driver Genes and Key Pathways of Pediatric Brain Tumors and Comparison of Molecular Pathogenesis Based on Pathologic Types [J].WORLD NEUROSURGERY,2017,107:990-1000.
APA：

Zhong Sheng,Wu Bo,Han Yujuan,Cao Yingshu,&Zhao Gang.(2017).Identification of Driver Genes and Key Pathways of Pediatric Brain Tumors and Comparison of Molecular Pathogenesis Based on Pathologic Types .WORLD NEUROSURGERY,107:990-1000.
MLA：

Zhong Sheng, et al. "Identification of Driver Genes and Key Pathways of Pediatric Brain Tumors and Comparison of Molecular Pathogenesis Based on Pathologic Types" .WORLD NEUROSURGERY 107(2017):990-1000.
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