Stab wounds are commonly encountered in clinical practice. However, iliopsoas abscess formation after an abdominal stab wound is relatively rare and its treatment is not well-documented. We report a case of a 20-year-old man who developed an iliopsoas abscess 10 days after an abdominal stab wound. In collaboration with orthopedic surgeons, wound debridement was performed twice, followed by vacuum sealing drainage (VSD), and implantation of antibiotic-loaded bone cement beads. Abdominal CT performed one month after surgery showed resolution of the abscess and acceptable recovery. No recurrence of symptoms was observed thereafter. Interdisciplinary collaboration is important for surgical treatment of complicated stab wounds. Use of VSD and implantation of antibiotic bead chain was found effective in treating the iliopsoas abscess.