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NKG2A is a NK cell exhaustion checkpoint for HCV persistence 期刊论文

编号：

886473bf-7dcf-4e77-8a8a-f1a8e75ec1a1
作者：

Zhang, Chao(张超)#^[1,2,3]Wang, Xiaomei(王晓美)#^[4]Li, Shuran^[1,2,3,5];Twelkmeyer, Trix^[1,2,6];Wang, Weihong^[1,2,3,5];Zhang, ShengYuan^[1,2,3,7];Wang, Shufeng^[8];Chen, Jizheng^[9,10];Jin, Xia(金侠)^[6]Wu, Yuzhang(吴玉章)^[8]Chen, Xinwen(陈新文)^[9,10]Wang, Shengdian(王盛典)^[3]Niu, Junqi(牛俊奇)^[4]Chen, Hairong*^[1,2,3]Tang, Hong(唐宏)*^[1,2,6,9,10]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2019 年 10 卷 ; APR 3
收录：
摘要：

Exhaustion of cytotoxic effector natural killer (NK) and CD8(+) T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined. Here we show, using the humanized C/O-Tg mice permissive for persistent HCV infection, that NK and CD8(+) T cells become sequentially exhausted shortly after their transient hepatic infiltration and activation in acute HCV infection. HCV infection upregulates Qa-1 expression in hepatocytes, which ligates NKG2A to induce NK cell exhaustion. Antibodies targeting NKG2A or Qa-1 prevents NK exhaustion and promotes NK-dependent HCV clearance. Moreover, reactivated NK cells provide sufficient IFN-gamma that helps rejuvenate polyclonal HCV CD8(+) T cell response and clearance of HCV. Our data thus show that NKG2A serves as a critical checkpoint for HCV-induced NK exhaustion, and that NKG2A blockade sequentially boosts interdependent NK and CD8(+) T cell functions to prevent persistent HCV infection.
推荐引用方式
GB/T 7714：

Zhang Chao,Wang Xiao-mei,Li Shu-ran, et al. NKG2A is a NK cell exhaustion checkpoint for HCV persistence [J].NATURE COMMUNICATIONS,2019,10.
APA：

Zhang Chao,Wang Xiao-mei,Li Shu-ran,Twelkmeyer Trix,&Tang Hong.(2019).NKG2A is a NK cell exhaustion checkpoint for HCV persistence .NATURE COMMUNICATIONS,10.
MLA：

Zhang Chao, et al. "NKG2A is a NK cell exhaustion checkpoint for HCV persistence" .NATURE COMMUNICATIONS 10(2019).
入库时间：

2/24/2020 1:36:53 PM
更新时间：

2/24/2020 1:36:53 PM
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