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Optimal conditions of LDR to protect the kidney from diabetes: Exposure to 12.5 mGy X-rays for 8 weeks efficiently protects the kidney from diabetes 期刊论文

编号：

887a3785-0aca-45cb-846b-321e9df90bf3
作者：

Cheng, Jie#^[1]Li, Fengsheng^[2,3];Cui, Jiuwei(崔久嵬)^[1]Guo, Weiying(郭蔚莹)^[1,2]Li, Cai(李才)^[1]Li, Wei(李薇)^[1]Wang, Guixia(王桂侠)^[1]Xing, Xiao^[4];Gao, Ying(高影)^[1]Ge, Yuanyuan^[1];Wang, Guanjun*^[1]Cai, Lu(蔡露)*^[2,5,6]
语种：

英文
期刊：

LIFE SCIENCES ISSN：0024-3205 2014 年 103 卷 1 期 (49 - 58) ; MAY 8
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关键词：

Low-dose radiation Diabetic nephropathy Renal remodeling Renal pathogenesis Radiation hormesis Radiation adaptive response
摘要：

Aims: We reported the attenuation of diabetes-induced renal dysfunction by exposure to multiple low-dose radiation (LDR) at 25 mGy every other day by suppressing renal oxidative damage. We here explored the optimal conditions of LDR to protect the kidney from diabetes.
Main methods: Male C57BL/6J mice with type I diabetes were induced with multiple injections of low-dose streptozotocin. Diabetic mice received whole body X-irradiation at a dose of 12.5, 25 or 50 mGy every other day for either 4 or 8 weeks. Age-matched normal mice were similarly irradiated at the dose of 25 mGy for 4 or 8 weeks. The renal function and histopathological changes were examined at the 4th and 8th weeks of the study.
Key findings: Diabetes induced renal dysfunction is shown by the decreased creatinine and increased microalbumin in the urine. Renal oxidative damage, detected by protein nitration and lipid oxidation, and remodeling, reflected by increased expression of connective tissue growth factor, collagen IV and fibronectin, were significantly increased in diabetic mice. All these renal pathological and function changes in diabetic mice were significantly attenuated by exposure to LDR at all regimens, among which, however, exposure to LDR at 12.5 mGy for 8 weeks provided the best protective effect on the kidney of diabetic mice.
Significance: Our results suggest that whole-body LDR at 12.5 mGy every other day for 8 weeks is the optimal condition of LDR to protect the kidney from diabetes. (C) 2014 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Cheng Jie,Li Fengsheng,Cui Jiuwei, et al. Optimal conditions of LDR to protect the kidney from diabetes: Exposure to 12.5 mGy X-rays for 8 weeks efficiently protects the kidney from diabetes [J].LIFE SCIENCES,2014,103(1):49-58.
APA：

Cheng Jie,Li Fengsheng,Cui Jiuwei,Guo Weiying,&Cai Lu.(2014).Optimal conditions of LDR to protect the kidney from diabetes: Exposure to 12.5 mGy X-rays for 8 weeks efficiently protects the kidney from diabetes .LIFE SCIENCES,103(1):49-58.
MLA：

Cheng Jie, et al. "Optimal conditions of LDR to protect the kidney from diabetes: Exposure to 12.5 mGy X-rays for 8 weeks efficiently protects the kidney from diabetes" .LIFE SCIENCES 103,1(2014):49-58.
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