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DNA demethylation of claudin-4 suppresses migration and invasion in laryngeal squamous carcinoma cells 期刊论文

编号：

88d169b3-f96e-470b-94c0-c437ed76f43a
作者：

Liu, Yafang(刘亚芳)#^[1]Chang, Kai^[1,2,3];Fu, Kexin^[1];Dong, Xinjie(董欣洁)^[1]Chen, Xiaoshuai(陈晓帅)^[1]Liu, Jixuan(刘继轩)^[1]Cui, Ni^[4];Ni, Jinsong(倪劲松)*^[1]
语种：

英文
期刊：

HUMAN PATHOLOGY ISSN：0046-8177 2018 年 75 卷 (71 - 80) ; MAY
收录：
摘要：

Claudin-4 (CLDN4) is a member of the claudin transmembrane protein family, which consists of integral membrane proteins that are components of the epithelial cell tight junctions; these tight junctions regulate movement of solutes and ions through the paracellular space. CLDN4 is also a differentiation marker and is believed to indicate an epithelial phenotype. However, the role of CLDN4 in laryngeal squamous carcinoma is still unclear. Here, we showed that CLDN4 expression was down-regulated in laryngeal squamous carcinoma tissues and negatively correlated with methyl-CpG-binding protein 2. In addition, CLDN4 was hypermethylated in HEp-2 cells. DNA demethylation of CLDN4 by 5-aza-2'-deoxycytidine suppressed migration and invasion of HEp-2 cells, whereas CLDN4 silencing restored the migration and invasion of HEp-2 cells. Therefore, CLDN4 plays a key role in laryngeal squamous carcinoma progression. (C) 2018 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Liu Yafang,Chang Kai,Fu Kexin, et al. DNA demethylation of claudin-4 suppresses migration and invasion in laryngeal squamous carcinoma cells [J].HUMAN PATHOLOGY,2018,75:71-80.
APA：

Liu Yafang,Chang Kai,Fu Kexin,Dong Xinjie,&Ni Jinsong.(2018).DNA demethylation of claudin-4 suppresses migration and invasion in laryngeal squamous carcinoma cells .HUMAN PATHOLOGY,75:71-80.
MLA：

Liu Yafang, et al. "DNA demethylation of claudin-4 suppresses migration and invasion in laryngeal squamous carcinoma cells" .HUMAN PATHOLOGY 75(2018):71-80.
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