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Protein Degradation Pathways after Brain Ischemia 期刊论文

编号：

8b8caeaa-abe9-42d5-b62e-cd577a8d40d1
作者：

Ge, Pengfei(葛鹏飞)#^[2]Zhang, Fan^[1];Zhao, Jingwei^[1,2]Liu, Chunli^[1];Sun, Liankun^[3];Hu, Bingren*^[1]
语种：

英文
期刊：

CURRENT DRUG TARGETS ISSN：1389-4501 2012 年 13 卷 2 期 (159 - 165) ; FEB
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关键词：

Ubiquitin microtubule-associated protein 1 light chain 3 (LC3) delayed neuronal death autophagy autophagosome lysosome protein aggregation protein folding organelle damage global ischemia focal ischemia
摘要：

There are two major routes for clearance of aberrant cellular components: (i) the ubiquitin-proteasomal system (UPS); and (ii) the autophagy pathway. The UPS degrades individual abnormal proteins, whereas the autophagy pathway is the chief route for bulk degradation of large abnormal protein aggregates and aberrant organelles. Impairments of the protein degradation pathways are closely tied with many human diseases. Brain ischemia leads to protein misfolding and aggregation, resulting in overproduction of protein aggregate-associated organelles. Brain ischemia also damages protein degradation pathways. This chapter will discuss molecular mechanisms underlying the impairments of the UPS and autophagy pathways and how such impairments lead to multiple organelle failure and delayed neuronal death after brain ischemia.
推荐引用方式
GB/T 7714：

Ge Pengfei,Zhang Fan,Zhao Jingwei, et al. Protein Degradation Pathways after Brain Ischemia [J].CURRENT DRUG TARGETS,2012,13(2):159-165.
APA：

Ge Pengfei,Zhang Fan,Zhao Jingwei,Liu Chunli,&Hu Bingren.(2012).Protein Degradation Pathways after Brain Ischemia .CURRENT DRUG TARGETS,13(2):159-165.
MLA：

Ge Pengfei, et al. "Protein Degradation Pathways after Brain Ischemia" .CURRENT DRUG TARGETS 13,2(2012):159-165.
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