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Iron-gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy 期刊论文

编号：

8baabd66-b264-4d5c-af7f-c0f88fe770fa
作者：

Li, YunQian(李蕴潜)#^[1]Xu, Meng^[2];Dhawan, Udesh^[3,4];Liu, WaiChing^[5];Wu, KouTing^[5];Liu, XinRui^[1];Lin, Chingpo^[1];Zhao, Gang(赵刚)^[1]Wu, YuChuan*^[3,6,7]Chung, RenJei*^[5]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF NANOMEDICINE ISSN：1178-2013 2018 年 13 卷 (5499 - 5509)
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关键词：

iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release
摘要：

Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug. Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron-gold alloy magnetic nanoparticles (Fe-Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug-nanoparticle conjugate (NFAMTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis. Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22 +/- 2.6 nm, while X-ray diffraction showed distinct 2. peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA-MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA-MTX conjugate, triggering a 95% decrease in cellular viability at 100 mu g/mL. Conclusion: The ability of NFA-MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected.
推荐引用方式
GB/T 7714：

Li Yun-Qian,Xu Meng,Dhawan Udesh, et al. Iron-gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy [J].INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:5499-5509.
APA：

Li Yun-Qian,Xu Meng,Dhawan Udesh,Liu Wai-Ching,&Chung Ren-Jei.(2018).Iron-gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy .INTERNATIONAL JOURNAL OF NANOMEDICINE,13:5499-5509.
MLA：

Li Yun-Qian, et al. "Iron-gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy" .INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):5499-5509.
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