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Activin A inhibits activities of lipopolysaccharide-activated macrophages via TLR4, not of TLR2 期刊论文

编号：

91dc38cc-d4b8-435f-bc6a-aa82f7e0066c
作者：

Li, Nan#^[1]Cui, Xueling^[1];Ge, Jingyan^[1];Li, Jiru^[1];Niu, Liman^[1];Liu, Haiyan^[1];Qi, Yan^[1];Liu, Zhonghui(柳忠辉)*^[1,2]Wang, Yinan(王轶楠)*^[1,2]
语种：

英文
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2013 年 435 卷 2 期 (222 - 228) ; MAY 31
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关键词：

Macrophages Activin A Lipopolysaccharide TLRs ActRIIA
摘要：

Activin A, a member of TGF-beta superfamily, is involved in either pro-inflammatory or anti-inflammatory responses. Our previous studies have reported that lipopolysaccharide (LPS) can simulate activin A secretion from macrophage, and activin A can induce rest macrophage activation in mice, but inhibit the activities of the activated macrophages. However, the relationship of activin and LPS actions and their mechanism are not well characterized. In the present study, the results showed that both activin A and LPS promoted the phagocytic activities of mouse peritoneal macrophages in vivo and in vitro, but activin A inhibited the phagocytosis of LPS-activated macrophages. Simultaneously, the results revealed that activin A inhibited the Toll-like receptor 4 (TLR4) expression on LPS-activated mouse peritoneal macrophages in vivo and in vitro, whereas there was no obvious change of TLR2 expression. Moreover, the results showed that activin A obviously reduced the TLR4 mRNA and protein expressions in LPS-activated macrophage cell line RAW264.7 cells, and the inhibitory effect of activin A on the TLR4 expression was significantly attenuated in Smad3 knock-down RAW264.7 cells. Interestingly, LPS promoted the expression of activin type HA receptor (ActRIIA) on mouse peritoneal macrophages in vivo, and also up-regulated ActRIIA and activin signal molecules Smad2, 3 mRNA expressions. These data suggest that activin A inhibits LPS action on macrophages in vivo via suppressing TLR4 expression, and LPS further augments the negative feedback action of activin A via up-regulating activin signaling transduction. (c) 2013 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Li Nan,Cui Xueling,Ge Jingyan, et al. Activin A inhibits activities of lipopolysaccharide-activated macrophages via TLR4, not of TLR2 [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,435(2):222-228.
APA：

Li Nan,Cui Xueling,Ge Jingyan,Li Jiru,&Wang Yinan.(2013).Activin A inhibits activities of lipopolysaccharide-activated macrophages via TLR4, not of TLR2 .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,435(2):222-228.
MLA：

Li Nan, et al. "Activin A inhibits activities of lipopolysaccharide-activated macrophages via TLR4, not of TLR2" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 435,2(2013):222-228.
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