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Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells 期刊论文

编号：

9231bef6-11e6-4996-ab5b-b11da643fe16
作者：

Zhang, Wenjia#^[1]Su, Jing^[2];Xu, Huadan^[2];Yu, Shanshan^[3];Liu, Yanan^[2];Zhang, Yong^[2];Sun, Liankun^[2];Yue, Ying(岳瑛)#*^[1]Zhou, Xiaoli#*^[2]
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2017 年 12 卷 6 期 ; JUN 15
收录：
摘要：

Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a promising anticancer therapeutic target. Our previous work suggests that coumarin compounds are potential inhibitors of PDKs. In this study, we used the ovarian cancer cell line SKOV3 as the model system and examined whether dicumarol (DIC), a coumarin compound, could inhibit ovarian cancer through targeting PDK1. We showed that DIC potently inhibited the kinase activity of PDK1, shifted the glucose metabolism from aerobic glycolysis to oxidative phosphorylation, generated a higher level of reactive oxygen species (ROS), attenuated the mitochondrial membrane potential (MMP), induced apoptosis, and reduced cell viability in vitro. The same phenotypes induced by DIC also were translated in vivo, leading to significant suppression of xenograft growth. This study not only identifies a novel inhibitor for PDK1, but it also reveals novel anticancer mechanisms of DIC and provides a promising anticancer therapy that targets the Warburg effect.
推荐引用方式
GB/T 7714：

Zhang Wenjia,Su Jing,Xu Huadan, et al. Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells [J].PLOS ONE,2017,12(6).
APA：

Zhang Wenjia,Su Jing,Xu Huadan,Yu Shanshan,&Zhou Xiaoli.(2017).Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells .PLOS ONE,12(6).
MLA：

Zhang Wenjia, et al. "Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells" .PLOS ONE 12,6(2017).
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