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Design, synthesis and antitumor activity of a novel series of PAC-1 analogues 期刊论文

编号：

92b5a68d-3fef-4eba-9d08-d143857d02db
作者：

Luo Haoming#^[1,2]Yang Chunling^[2];Zhang Xiaoying(张晓荧)^[3]Zhao Mingming^[4];Jiang Dan^[2];Xiao Junhai(肖军海)*^[2]Yang Xiaohong(杨晓虹)*^[1]Li Song^[2];
语种：

英文
期刊：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES ISSN：1005-9040 2013 年 29 卷 5 期 (906 - 910) ; OCT
收录：
关键词：

PAC-1 analogue Anticancer activity MTT assay HL60
摘要：

A novel series of first procaspase activating compound(PAC-1) analogues was designed, synthesized and evaluated for antitumor activity towards two cell lines[human promyelocytic leukemia cell line(HL60) and human embryonic lung fibroblast cell line(HLF)] by the MTT[3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazo-liumromide]_method in vitro. The structures of all the compounds were confirmed by H-1 NMR, MS and elemental analysis. Among the compounds synthesized,(E)-2-[(3-{[4-(tert-butyl)benzyl](methyl)amino}propyl)(methyl)amino]-N"-[4-(diethylamino)-2-hydroxybenzylidene]acetohydrazide(compound 6n) exhibits a good anti-proliferative activity to the majority of tumor cells tested, and selectively cleaves cancer cells. Thus, compound 6n was identified as promising lead compound for further structural modification.
推荐引用方式
GB/T 7714：

Luo Hao-ming,Yang Chun-ling,Zhang Xiao-ying, et al. Design, synthesis and antitumor activity of a novel series of PAC-1 analogues [J].CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2013,29(5):906-910.
APA：

Luo Hao-ming,Yang Chun-ling,Zhang Xiao-ying,Zhao Ming-ming,&Li Song.(2013).Design, synthesis and antitumor activity of a novel series of PAC-1 analogues .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,29(5):906-910.
MLA：

Luo Hao-ming, et al. "Design, synthesis and antitumor activity of a novel series of PAC-1 analogues" .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 29,5(2013):906-910.
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