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A Patient With Progressive Cognitive Decline and Periodic Abnormal Waves in EEG: PLEDs of Neurosyphilis or PSDs of Creutzfeldt-Jakob Disease? 期刊论文

编号：

9612374f-9241-4015-b5c7-c171555fa7b0
作者：

Lv, Yudan(吕玉丹)#^[1]Chu, Fengna^[1];Meng, Hongmei(孟红梅)^[1]Wang, Zan^[1];Cui, Li(崔俐)*^[1]
语种：

英文
期刊：

CLINICAL EEG AND NEUROSCIENCE ISSN：1550-0594 2014 年 45 卷 3 期 (218 - 221) ; JUL
收录：
关键词：

neurosyphilis periodic lateralized epileptiform discharge (PLED) seizures
摘要：

We report one Chinese patient with neurosyphilis exhibiting periodic lateralized epileptiform discharges (PLEDs) in the electroencephalogram (EEG). The patient (male, 59 years old) manifested with progressive cognitive decline and abnormal behavior. After several days, he gradually lost contact with others, and fell into a coma. EEG revealed periodic abnormal waves, predominantly located in the right anterior frontal region. The serum and cerebrospinal fluid Venereal Disease Research Laboratory test and Treponema pallidum hemagglutination assay were positive. Magnetic resonance imaging (MRI) of brain showed focal atrophy in the right frontal and temporal region. Diffusion-weighted MRI showed "lace sign" in cortex, which could be seen as an early and special feature in Creutzfeldt-Jakob disease (CJD). To differentiate "PLEDs of neurosyphilis on EEG" from "periodic synchronous discharges (PSD) of CJD on EEG," we treated this patient with diazepam 20 mg intravenously. After 10 minutes, periodic abnormal waves on EEG disappeared, with improved mental status, which confirmed the diagnosis of PLEDs of neurosyphilis. Then, after the treatment with penicillin, the patient improved and returned to work.
推荐引用方式
GB/T 7714：

Lv Yudan,Chu Fengna,Meng Hongmei, et al. A Patient With Progressive Cognitive Decline and Periodic Abnormal Waves in EEG: PLEDs of Neurosyphilis or PSDs of Creutzfeldt-Jakob Disease? [J].CLINICAL EEG AND NEUROSCIENCE,2014,45(3):218-221.
APA：

Lv Yudan,Chu Fengna,Meng Hongmei,Wang Zan,&Cui Li.(2014).A Patient With Progressive Cognitive Decline and Periodic Abnormal Waves in EEG: PLEDs of Neurosyphilis or PSDs of Creutzfeldt-Jakob Disease? .CLINICAL EEG AND NEUROSCIENCE,45(3):218-221.
MLA：

Lv Yudan, et al. "A Patient With Progressive Cognitive Decline and Periodic Abnormal Waves in EEG: PLEDs of Neurosyphilis or PSDs of Creutzfeldt-Jakob Disease?" .CLINICAL EEG AND NEUROSCIENCE 45,3(2014):218-221.
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