首页 / 院系成果 / 成果详情页

Valproic acid alters differential protein expression in SH-SY5Y cells 期刊论文

编号：

9d91b8b3-f963-4c73-a0d7-4dbbe20c8898
作者：

Dong, Zhong#^[1]Wang, Ying^[1];Chang, Ming(常明)^[1]Li, Guoyi^[1];Hu, Linsen(胡林森)*^[1]
语种：

英文
期刊：

NEURAL REGENERATION RESEARCH ISSN：1673-5374 2011 年 6 卷 27 期 (2134 - 2139) ; SEP 25
收录：
关键词：

valproic acid two-dimensional difference gel electrophoresis matrix-assisted laser desorption-ionization SH-SY5Y cells proteomics neural regeneration
摘要：

This study sought to identify differentially expressed proteins in SH-SY5Y cells treated with valproic acid, using two-dimensional difference gel electrophoresis analysis. Three proteins were unambiguously identified: the eukaryotic translation initiation factor 4A isoform 1 and ATP6V1B2 protein were downregulated, while the heterogeneous nuclear ribonucleoprotein K was upregulated. Moreover, all three proteins are associated with altered expression due to oxidative stress.
Matrix-assisted laser desorption/ionization-time of flight mass spectrometry and protein immunoblotting assay confirmed the differential expression of eukaryotic translation initiation factor 4A isoform 1. The results indicate that valproic acid exerts an antioxidation effect by regulating the expression of eukaryotic translation initiation factor 4A isoform 1.
推荐引用方式
GB/T 7714：

Dong Zhong,Wang Ying,Chang Ming, et al. Valproic acid alters differential protein expression in SH-SY5Y cells [J].NEURAL REGENERATION RESEARCH,2011,6(27):2134-2139.
APA：

Dong Zhong,Wang Ying,Chang Ming,Li Guoyi,&Hu Linsen.(2011).Valproic acid alters differential protein expression in SH-SY5Y cells .NEURAL REGENERATION RESEARCH,6(27):2134-2139.
MLA：

Dong Zhong, et al. "Valproic acid alters differential protein expression in SH-SY5Y cells" .NEURAL REGENERATION RESEARCH 6,27(2011):2134-2139.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：17  下载次数：0

分享到：

浏览次数：17

下载次数：0

打印次数：0