The pathogenesis of tardive dyskinesia (TD) may involve neurodegeneration and associated dysfunction of brain-derived neurotrophic factor (BDNF) for the survival and maintenance of function in neurons. We therefore compared serum BDNF levels in schizophrenic patients with (n = 129) and without TD (n = 235), and normal controls (n = 323). Assessments included the abnormal involuntary movement scale (AIMS) and the positive and negative syndrome scale (PANSS). Our results were that patients with TD had lower serum BDNF levels than those without TD and normals. Lower serum BDNF levels were correlated with greater PANSS negative subscores, but not correlated with the AIMS scores. Serum BDNF levels did not differ between patients on typical and atypical antipsychotics and were not correlated with antipsychotic doses or years of exposure. We concluded that decreased BDNF levels might be associated with TD pathophysiology and more negative symptoms of schizophrenia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
[1]Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China.
[2]Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
[3]Beijing HuiLongGuan Hosp, Beijing, Peoples R China.
[4]Inner Mongolia Med Coll, Hohhot, Peoples R China.
[5]Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
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