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Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs 期刊论文 WOS高被引论文

编号：

C7F588BB2004C72A74E9B00A75B5C9B2
作者：

Teng, Shiyong(滕士勇)#^[1,2]Han, Yandong^[3];Hu, Yang^[2];Li, Jinshuo^[2];Wang, Min^[2];Guo, Zilong*^[3]Yang, Wensheng(杨文胜)*^[2]
语种：

英文
期刊：

JOURNAL OF COLLOID AND INTERFACE SCIENCE ISSN：0021-9797 2023 年 630 卷 (266 - 273) ; JAN 15
收录：
关键词：

Organosilica Capsules Hollow Swellable Hydrophobic drugs
摘要：

As a new kind of drug carrier, practical applications of hollow periodic mesoporous organosilica (HPMO) have been greatly limited by their low loading capacity for hydrophobic drugs. In this work, we demon-strated the preparation of HPMO capsules with tunable shell thickness by using 1,2-bis(triethoxysilyl) ethane as the precursor. The capsules with thin shells and thus low Young''s modulus showed excellent swellability to organic solvents containing hydrophobic drugs. As a result, hydrophobic drugs, i.e., pacli-taxel (PTX) could be loaded into the hollow interior of the HPMO capsules with 4 nm shell at an efficiency of ca. 120 %. The as-prepared PTX-loaded HPMO capsules were dispersible in aqueous media and showed improved performance in killing cancer cells compared to free PTX.(c) 2022 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Teng Shiyong,Han Yandong,Hu Yang, et al. Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs [J].JOURNAL OF COLLOID AND INTERFACE SCIENCE,2023,630:266-273.
APA：

Teng Shiyong,Han Yandong,Hu Yang,Li Jinshuo,&Yang Wensheng.(2023).Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs .JOURNAL OF COLLOID AND INTERFACE SCIENCE,630:266-273.
MLA：

Teng Shiyong, et al. "Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs" .JOURNAL OF COLLOID AND INTERFACE SCIENCE 630(2023):266-273.
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