首页 / 院系成果 / 成果详情页

Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs

  • 编号:
    C7F588BB2004C72A74E9B00A75B5C9B2
  • 作者:
    Teng, Shiyong[1,2] Han, Yandong[3] Hu, Yang[2] Li, Jinshuo[2] Wang, Min[2] Guo, Zilong[3] Yang, Wensheng[2]
  • 语种:
    英文
  • 期刊:
    JOURNAL OF COLLOID AND INTERFACE SCIENCE ISSN:0021-9797 2023 年 630 卷 (266 - 273) ; JAN 15
  • 收录:
  • 关键词:
  • 摘要:

    As a new kind of drug carrier, practical applications of hollow periodic mesoporous organosilica (HPMO) have been greatly limited by their low loading capacity for hydrophobic drugs. In this work, we demon-strated the preparation of HPMO capsules with tunable shell thickness by using 1,2-bis(triethoxysilyl) ethane as the precursor. The capsules with thin shells and thus low Young''s modulus showed excellent swellability to organic solvents containing hydrophobic drugs. As a result, hydrophobic drugs, i.e., pacli-taxel (PTX) could be loaded into the hollow interior of the HPMO capsules with 4 nm shell at an efficiency of ca. 120 %. The as-prepared PTX-loaded HPMO capsules were dispersible in aqueous media and showed improved performance in killing cancer cells compared to free PTX.(c) 2022 Elsevier Inc. All rights reserved.

  • 推荐引用方式
    GB/T 7714:
    Teng Shiyong,Han Yandong,Hu Yang, et al. Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs [J].JOURNAL OF COLLOID AND INTERFACE SCIENCE,2023,630:266-273.
  • APA:
    Teng Shiyong,Han Yandong,Hu Yang,Li Jinshuo,&Yang Wensheng.(2023).Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs .JOURNAL OF COLLOID AND INTERFACE SCIENCE,630:266-273.
  • MLA:
    Teng Shiyong, et al. "Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs" .JOURNAL OF COLLOID AND INTERFACE SCIENCE 630(2023):266-273.
浏览次数:34 下载次数:0
浏览次数:34
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部