首页 / 院系成果 / 成果详情页

Oxymatrine Lightened the Inflammatory Response of LPS-Induced Mastitis in Mice Through Affecting NF-kappa B and MAPKs Signaling Pathways 期刊论文

编号：

a13ccdcf-dce4-468c-91c2-0c495329feb0
作者：

Yang, Zhengtao(杨正涛)#^[1]Yin, Ronglan^[2];Cong, Yunfeng(丛云凤)^[3]Yang, Zhanqing^[1];Zhou, Ershun^[1];Wei, Zhengkai^[1];Liu, Zhicheng^[1];Cao, Yongguo^[1];Zhang, Naisheng(张乃生)*^[1]
语种：

英文
期刊：

INFLAMMATION ISSN：0360-3997 2014 年 37 卷 6 期 (2047 - 2055) ; DEC
收录：
关键词：

oxymatrine LPS mastitis NF-kappa B MAPKs
摘要：

Mastitis, an inflammatory reaction of the mammary gland, is recognized as one of the most costly diseases in dairy cattle. Oxymatrine, one of the alkaloids extracted from Chinese herb Sophora flavescens Ait, has been reported to have many biological activities, such as anti-inflammatory, anti-virus, and anti-hepatic fibrosis properties. The aim of this study was to investigate the protective effect and the anti-inflammatory mechanism of oxymatrine on lipopolysaccharide (LPS)-induced mastitis in mice. The mouse mastitis was induced by 10 mu g of LPS for 24 h. Oxymatrine was intraperitoneally administered with the dose of 30, 60, and 120 mg/kg 1 h before and 12 h after LPS induction. The results showed that oxymatrine significantly attenuated the damage of the mammary gland induced by LPS. Oxymatrine inhibited the phosphorylation of NF-kappa B p65 and I kappa B in NF-kappa B signal pathway and reduced the phosphorylation of p38, ERK, and JNK in mitogen-activated protein kinase (MAPKs) signal pathway. The results showed that oxymatrine had a protective effect on LPS-induced mastitis, and the anti-inflammatory mechanism of oxymatrine was related to the inhibition of NF-kappa B and MAPKs signal pathways.
推荐引用方式
GB/T 7714：

Yang Zhengtao,Yin Ronglan,Cong Yunfeng, et al. Oxymatrine Lightened the Inflammatory Response of LPS-Induced Mastitis in Mice Through Affecting NF-kappa B and MAPKs Signaling Pathways [J].INFLAMMATION,2014,37(6):2047-2055.
APA：

Yang Zhengtao,Yin Ronglan,Cong Yunfeng,Yang Zhanqing,&Zhang Naisheng.(2014).Oxymatrine Lightened the Inflammatory Response of LPS-Induced Mastitis in Mice Through Affecting NF-kappa B and MAPKs Signaling Pathways .INFLAMMATION,37(6):2047-2055.
MLA：

Yang Zhengtao, et al. "Oxymatrine Lightened the Inflammatory Response of LPS-Induced Mastitis in Mice Through Affecting NF-kappa B and MAPKs Signaling Pathways" .INFLAMMATION 37,6(2014):2047-2055.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：22  下载次数：0

分享到：

浏览次数：22

下载次数：0

打印次数：0