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Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study 期刊论文

编号：

a239ab05-3701-4571-babf-58bbce175152
作者：

Sun, Lichao(孙立超)#^[1]Qiu, Jiqing(邱吉庆)^[2]Wang, Guangming^[2];Lin, Weihong(林卫红)*^[3]Zhang, Nan(张楠)^[1]
语种：

英文
期刊：

JOURNAL OF CHROMATOGRAPHIC SCIENCE ISSN：0021-9665 2015 年 53 卷 9 期 (1597 - 1602) ; OCT
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摘要：

A simple and selective liquid chromatography-tandem mass spectrometric method for determination of valtrate in rat plasma was developed in this study. Chromatographic separation was achieved on a Thermo BDS HYPERSIL C-18 column using acetonitrile-water-formic acid (75 : 25 : 0.1, v/v/v) as mobile phase in an isocratic mode of elution at a flow rate of 300 mu L/min. MS-MS detection was performed in a positive ion electrospray ionization mode with the ion transitions 445.2 -> 219.2 for valtrate and 355.2 -> 135.1 for internal standard (sesamin). The developed method exhibited a linear dynamic range over 5.65-1695 ng/mL for valtrate in rat plasma. The overall extraction recovery of valtrate from plasma was 86.13-88.32%. The intra- and inter-day accuracy and precision were within the pre-defined limits of <= 15% at all concentrations. The method was successfully applied to pharmacokinetic studies of valtrate in rats.
推荐引用方式
GB/T 7714：

Sun Lichao,Qiu Jiqing,Wang Guangming, et al. Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study [J].JOURNAL OF CHROMATOGRAPHIC SCIENCE,2015,53(9):1597-1602.
APA：

Sun Lichao,Qiu Jiqing,Wang Guangming,Lin Weihong,&Zhang Nan.(2015).Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study .JOURNAL OF CHROMATOGRAPHIC SCIENCE,53(9):1597-1602.
MLA：

Sun Lichao, et al. "Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study" .JOURNAL OF CHROMATOGRAPHIC SCIENCE 53,9(2015):1597-1602.
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