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Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD 期刊论文

编号：

a7eefe43-236b-4af1-8b9c-c8e0e62c88a6
作者：

Zhang, Hui#^[1,2]Xu, Hongqin(徐洪芹)#^[1,3]Wu, Ruihong(吴瑞红)^[1,3]Yu, Ge(于鸽)^[1]Sun, Haibo^[1]Lv, Juan^[1]Wang, Xiaomei(王晓美)^[1,3]Chi, Xiumei(迟秀梅)^[1,3]Gao, Xiuzhu(高修竹)^[1,3]Kong, Fei(孔菲)^[1]Zhang, Mingyuan(张明媛)^[1]Hang, Lei(杭蕾)^[1]Jiang, Jing(姜晶)^[4]Pan, Yu(潘煜)*^[1]Niu, Junqi(牛俊奇)*^[1,3]
语种：

英文
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2019 年 9 卷 ; FEB 13
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摘要：

Hepatitis C virus (HCV) infection greatly increases the risk of nephropathy. In this observational study, we aimed to explore the relationship between viral hepatitis infection and chronic kidney disease (CKD), identify risk factors, and determine the effect of antiviral treatment on CKD in Chinese patients with chronic HCV infection. A total of 2,435 study subjects were enrolled and divided into four groups: the HCV infection, HBV infection, HBV and HCV co-infection, and uninfected control groups. Of these, 207 patients with chronic hepatitis C (CHC) were given standard dual therapy[subcutaneous injection of recombinant interferon (IFN)-alpha 2b and oral ribavirin (RBV)] for 48 weeks. We found that the prevalence of CKD gradually increased with age in all groups and was significantly increased in patients 60 years or older. Multivariate logistic regression analyses showed that persistent HCV infection was significantly associated with CKD[odds ratio (OR), 1.33; 95% confidence interval (CI), 1.06-1.66; P = 0.013], whereas there was no significant link between CKD and spontaneous HCV clearance (OR, 1.23; 95% CI, 0.79-1.90; P = 0.364), HBV infection (OR, 0.73; 95% CI, 0.44-1.19; P = 0.201), or HBV/HCV co-infection (OR, 1.40; 95% CI, 0.81-2.40; P = 0.234). Notably, after anti-HCV therapy, the serum creatinine concentration was significantly decreased (76.0, 75.5-79.4 mu mol/L) from the pretreatment level (95.0, 93.0-97.2 mu mol/L), both in patients who showed an end of treatment virological response (ETVR) and those who did not (P < 0.001). Also, in both the ETVR and non-ETVR groups, the percentages of patients with an estimated glomerular filtration rate (eGFR) = 90 ml/min/1.73 m(2) increased significantly (P < 0.001), whereas the percentages of those with an eGFR < 60 ml/min/1.73 m(2) significantly decreased (P < 0.001). In conclusion, persistent HCV infection was independently associated with CKD, and antiviral treatment with IFN plus RBV can improve renal function and reverse CKD in HCV-infected patients.
推荐引用方式
GB/T 7714：

Zhang Hui,Xu Hongqin,Wu Ruihong, et al. Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD [J].SCIENTIFIC REPORTS,2019,9.
APA：

Zhang Hui,Xu Hongqin,Wu Ruihong,Yu Ge,&Niu Junqi.(2019).Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD .SCIENTIFIC REPORTS,9.
MLA：

Zhang Hui, et al. "Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD" .SCIENTIFIC REPORTS 9(2019).
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