首页 / 院系成果 / 成果详情页

Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection? 期刊论文

编号：

ad96e31f-f448-48ab-948c-fb8dccfd4f53
作者：

Yu, GuiMei#^[1]Liu, Di^[1];Yuan, Na^[1];Liu, BaoHua(刘宝华)*^[2]
语种：

English
期刊：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY ISSN：0892-3973 2018 年 40 卷 4 期 (273 - 277)
收录：
关键词：

Acid-sensing ion channels 3 rheumatoid arthritis inflammation synoviocytes pain
摘要：

Acid-sensing ion channels (ASIC) are voltage-independent cationic channels that open in response to decrease in extracellular pH. Amongst different subtypes, ASIC3 has received much attention in joint inflammatory conditions including rheumatoid arthritis. There have been a number of studies showing that there is an increase in expression of ASIC3 on nerve afferents supplying joints in response to inflammatory stimulus. Accordingly, a number of selective as well as nonselective ASIC3 inhibitors have shown potential in attenuating pain and inflammation in animal models of rheumatoid arthritis. On the other hand, there have been studies showing that ASIC3 may exert protective effects in joint inflammation. ASIC(-/-) animals, without ASIC3 genes, exhibit more joint inflammation and destruction in comparison to ASIC(+/+) animals. The present review discusses the dual nature of ASIC3 in joint inflammation with possible mechanisms.
推荐引用方式
GB/T 7714：

Yu Gui-Mei,Liu Di,Yuan Na, et al. Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection? [J].IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,2018,40(4):273-277.
APA：

Yu Gui-Mei,Liu Di,Yuan Na,Liu Bao-Hua.(2018).Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection? .IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,40(4):273-277.
MLA：

Yu Gui-Mei, et al. "Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection?" .IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 40,4(2018):273-277.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：7  下载次数：0

分享到：

浏览次数：7

下载次数：0

打印次数：0