Use of inorganic nanoparticles is expectedly improving the prospects of chemotherapy and diagnosis. Here, we report a facile approach to synthesize water dispersible, superparamagnetic manganese ferrite (MnFe2O4) nanoparticles at relatively low temperature. Subsequently, these MnFe2O4 nanoparticles are integrated with acid degradable mesoporous ZnO nanoparticles to attain a platform for simultaneous magnetic resonance imaging (MRI) and acid triggered anticancer drug delivery. Drug release was evaluated by tuning the pH of buffer solutions to mimic intracellular environment, which demonstrated a biorelevant acid sensitive release behavior. In vitro cell study congruently demonstrated an excellent concentration-dependent cytotoxicity on pancreatic cancer cells, with IC50 of 3 mu g/mL composite concentration. As far as imaging results are concerned, relaxivity value (r(2)) value of our system was found to be measurably higher than commercial T-2 MRI contrast agent Ferridex (63.5 mM(-1) s(-1)).
This smart nanosystem can be a step forward towards the realization of concurrent effective therapy, monitoring of nanocarrier distribution and disease evolution. (C) 2013 Elsevier Inc. All rights reserved.
[1]Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China.
[2]Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China.
[3]Jilin Univ, Hosp 1, Norman Bethune Coll Med, Dept Radiol, Changchun 130021, Peoples R China.
[4]Jilin Univ, Coll Construct Engn, Changchun 130026, Peoples R China.
(8.0+极速模式)