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Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients 期刊论文

编号：

b4a49b24-56ff-41c0-a1b5-5ad3f5eb02e4
作者：

Wang, Huan#^[1]Xu, Hongqin^[1];Qu, Limei(曲丽梅)^[2]Wang, Xiaomei^[1];Wu, Ruihong(吴瑞红)^[1]Gao, Xiuzhu^[1];Jin, Qinglong(金清龙)^[1]Niu, Junqi(牛俊奇)*^[1,3,4]
语种：

英文
期刊：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY ISSN：0954-691X 2016 年 28 卷 9 期 (997 - 1002) ; SEP
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关键词：

chronic liver disease fibrosis globulin inflammation noninvasive marker red blood cell distribution width
摘要：

Aims We aimed to develop new simple predictive models for significant fibrosis and inflammation in chronic hepatitis patients using routine laboratory parameters.
Methods A total of 218 patients who had undergone liver biopsy were enrolled in our study. Among these, 116 had chronic hepatitis B, 65 had primary biliary cirrhosis, and 37 had autoimmune hepatitis. Patients were divided into two groups: absent-mild (S0-S1, G0-G1) and moderate-severe (S2-S4, G2-G4) according to the histologic severity of liver fibrosis and inflammation. All common demographics and routine laboratory parameters were analyzed.
Results Red blood cell distribution width (RDW) and globulin values increased with progressive liver fibrosis and inflammation. After adjustment for other potent predictors, liver fibrosis was associated independently with RDW and platelet (odds ratio=0.976 and 1.487, respectively), whereas significant inflammation was associated independently with globulin, alanine aminotransferase, red blood cell, and platelet (odds ratio = 1.153, 1.017, 0.392, and 1.487, respectively). The sensitivity and specificity of model A were 73.4 and 79.1% for the detection of significant liver fibrosis [area under the receiver-operating characteristic curve (AUROC) = 0.81, P<0.001]. The sensitivity and specificity of model B were 75.9 and 88.9% for predicting advanced liver inflammation (AUROC = 0.89, P<0.001). Compared with pre-existing indicators, model A achieved the highest AUROC (0.81, P<0.001) for liver fibrosis, whereas model B showed the highest AUROC (0.89, P<0.001) for liver inflammation.
Conclusion RDW may provide a useful clinical value for predicting liver fibrosis; meanwhile, globulin may provide a useful clinical value for predicting liver inflammation in chronic hepatitis patients with other markers. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Huan,Xu Hongqin,Qu Limei, et al. Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients [J].EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2016,28(9):997-1002.
APA：

Wang Huan,Xu Hongqin,Qu Limei,Wang Xiaomei,&Niu Junqi.(2016).Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients .EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,28(9):997-1002.
MLA：

Wang Huan, et al. "Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients" .EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 28,9(2016):997-1002.
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