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4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress 期刊论文

编号：

b52448cf-682a-4ad7-a722-67729b52c419
作者：

Ma, Tianjiao(马天骄)#^[1,2]Zheng, Zongyu^[2,3];Guo, Hua^[2];Lian, Xin^[2,3];Rane, Madhavi J.^[4];Cai, Lu^[2,5,6,7];Kim, Ki Soo^[8];Kim, Kyoung Tae^[8];Zhang, Zhiguo(张志国)*^[9]Bi, Liqi(毕黎琦)*^[1]
语种：

英文
期刊：

TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN：0041-008X 2019 年 370 卷 (93 - 105) ; MAY 1
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关键词：

4-O-Methylhonokiol Diabetic Nephropathy NE-kappa B AMPR Nrf2
摘要：

Diabetic nephropathy (DN) is one of the most serious long-term complications of type 2 diabetes (T2D). 4-O-methylhonokiol (MH) is one of the biologically active ingredients extracted from the Magnolia stem bark. In this study, we aim to elucidate whether treatment with MH can ameliorate or slow-down progression of DN in a T2D murine model and, if so, whether the protective response of MH correlates with AMPK-associated anti-oxidant and anti-inflammatory effects. To induce T2D, mice were fed normal diet (ND) or high fat diet (HFD) for 3 months to induce insulin resistance, followed by an intraperitoneal injection of STZ to induce hyperglycemia. Both T2D and control mice received gavage containing vehicle or MH once diabetes onset for 3 months. Once completing 3-month MH treatment, five mice from each group were sacrificed as 3 month time-point. The rest mice in each group were sacrificed 3 months later as 6 month time-point. In T2D mice, the typical DN symptoms were induced as expected, reflected by increased proteinuria, renal lipid accumulation and lipotoxic effects inducing oxidative stress, and inflammatory reactions, and final fibrosis. However, these typical DN changes were significantly prevented by MH treatment for 3 months and even at 3 months post-MH withdrawal. Mechanistically, MH renal-protection from DN may be related to lipid metabolic improvement and oxidative stress attenuation along with increases in AMPK/PGC-1 alpha/CPT1B-mediated fatty acid oxidation and Nrf2/SOD2-mediated anti-oxidative stress. Results showed the preventive effect of MH on the renal oxidative stress and inflammation in DN.
推荐引用方式
GB/T 7714：

Ma Tianjiao,Zheng Zongyu,Guo Hua, et al. 4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress [J].TOXICOLOGY AND APPLIED PHARMACOLOGY,2019,370:93-105.
APA：

Ma Tianjiao,Zheng Zongyu,Guo Hua,Lian Xin,&Bi Liqi.(2019).4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress .TOXICOLOGY AND APPLIED PHARMACOLOGY,370:93-105.
MLA：

Ma Tianjiao, et al. "4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress" .TOXICOLOGY AND APPLIED PHARMACOLOGY 370(2019):93-105.
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