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Serum protein marker panel for predicting preeclampsia 期刊论文

编号：

b730d399-53e8-4b0e-90bc-f5f3ccb62226
作者：

Cui, Lifeng(崔丽峰)#^[1]Shu, Chang(舒畅)^[2]Liu, Zitao^[3];Tong, Weihua(佟伟华)^[4]Cui, Miao^[5];Wei, Chengguo^[6];Tang, Jian Jenny^[7];Liu, Xiufen(刘秀芬)^[8]Hai, Hujing^[9];Jiang, Jing(姜晶)^[10]He, Jin(何津)^[2]Zhang, David Y.^[5];Ye, Fei^[5];Li, Yulin(李玉林)*^[1]
语种：

English
期刊：

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH ISSN：2210-7789 2018 年 14 卷 (279 - 285) ; OCT
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关键词：

Preeclampsia Diagnostics of preeclampsia Severe features of preeclampsia Pregnancy Diagnostic biomarkers
摘要：

Background: Preeclampsia is a multi-system disorder in pregnancy which has no effective treatment. The diagnosis of preeclampsia is based on clinical presentation and routine laboratory tests. Objective: This study aimed at identifying serum protein markers for diagnosis of preeclampsia and predicting its severe features. Study design: In total, 172 pregnant women were enrolled in this study including 110 subjects with preeclampsia and 62 normotensive subjects. Eleven serum proteins (VEGF, sFlt-1, sEndoglin, PlGF, sEGFR, prolactin, PTX3, PAI-1, NGAL, IL-27, COX-2) were assessed using Luminex multiplex immunoassay and ELISA. Results: The levels of seven proteins (sFlt-1, VEGF, sEndoglin, sEGFR, PlGF, NGAL, COX-2) correlated with preeclampsia, and 4 proteins (VEGF, sEndoglin, PlGF, sEGFR) were identified as independent factors associated with preeclampsia. The levels of three proteins (sEndoglin, PTX3, sFlt-1) correlated with severe features of preeclampsia, and three variables (serum creatinine, platelet count and sEndoglin) were identified as in- dependent factors in predicting severe features of preeclampsia. Conclusions: A combination of serum protein markers (VEGF, sEndoglin, PlGF, sEGFR) and clinical variables (serum creatinine, platelet count and sEndoglin) could be used as analytical tool in diagnosis of preeclampsia and its severe features, respectively. Serum sEGFR, a novel biomarker in preeclampsia, may be involved in the pathogenesis of preeclampsia.
推荐引用方式
GB/T 7714：

Cui Lifeng,Shu Chang,Liu Zitao, et al. Serum protein marker panel for predicting preeclampsia [J].PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH,2018,14:279-285.
APA：

Cui Lifeng,Shu Chang,Liu Zitao,Tong Weihua,&Li Yulin.(2018).Serum protein marker panel for predicting preeclampsia .PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH,14:279-285.
MLA：

Cui Lifeng, et al. "Serum protein marker panel for predicting preeclampsia" .PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 14(2018):279-285.
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