首页 / 院系成果 / 成果详情页

Protein marker profiling in different T classification in laryngeal squamous cell carcinoma 期刊论文

编号：

c1e90355-9341-4806-8428-5fb7b6e9b2db
作者：

Chen, Weilun(陈玮伦)#*^[1]Ye, Fei^[2];Cui, Miao^[2];Sikora, Andrew G.^[3];Wang, Xin(汪欣)^[1]Wang, Ping(王苹)^[1]Cui, Xiangyan(崔香艳)^[1]Guo, Xiaofeng(郭晓峰)^[1]Zhu, Wei(祝威)^[1]Zhang, David Y.*^[2]
语种：

英文
期刊：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK ISSN：1043-3074 2015 年 37 卷 3 期 (357 - 365) ; MAR
收录：
关键词：

protein pathway array biomarkers protein networks carcinoma larynx
摘要：

BackgroundThe identification of specific biomarkers related to laryngeal squamous cell carcinoma (SCC) will be helpful in early detection and determination of reasonable treatment options, which are crucial for the prognosis of patients with laryngeal SCC. The purpose of this study was to profile the protein markers that can be used for diagnosis and prognosis of laryngeal SCC and to observe laryngeal SCC progression with distinct stages of malignant transformation.
MethodsTwo hundred twenty-five proteins were tested in 84 pairs of tumors and adjacent nontumor mucosa samples using protein pathway arrays (PPAs). Ingenuity pathway analysis (IPA) enrichment analysis was performed and protein expression profiles in different T classification were mapped by grid analysis of time-series expression (GATE).
ResultsAmong 16 proteins differently expressed between tumors and normal tissues, we selected 9 proteins (TTF-1, CDK2, Eg5, proliferating cell nuclear antigen [PCNA], Bcl-xL, 14-3-3, p27, SRC-1, cytokeratin 18) as markers for classification. From the IPA analysis, we observed a more malignant transformation from T3 to T4 at the protein level and described the changing patterns of the proteins" expression in this progression. JAK2, keratin 10, and IL-3R were identified as markers for prognosis. The risk model based on histological grade, T classification, N classification, JAK2, and IL-3R can predict the prognosis with 85.5% accuracy.
ConclusionThis study indicated that dysregulated signaling proteins can be selected as useful biomarkers for tumor classification and predicting the outcome in patients with laryngeal SCC. The changing patterns of the proteins" expression in different stages were related to the more malignant transformation and further studies will focus on the role of these proteins in laryngeal SCC progression. (c) 2014 Wiley Periodicals, Inc. Head Neck, 37: 357-365, 2015
推荐引用方式
GB/T 7714：

Chen Weilun,Ye Fei,Cui Miao, et al. Protein marker profiling in different T classification in laryngeal squamous cell carcinoma [J].HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,2015,37(3):357-365.
APA：

Chen Weilun,Ye Fei,Cui Miao,Sikora Andrew G.,&Zhang David Y..(2015).Protein marker profiling in different T classification in laryngeal squamous cell carcinoma .HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,37(3):357-365.
MLA：

Chen Weilun, et al. "Protein marker profiling in different T classification in laryngeal squamous cell carcinoma" .HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 37,3(2015):357-365.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：58  下载次数：0

分享到：

浏览次数：58

下载次数：0

打印次数：0