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Zinc delays the progression of obesity-related glomerulopathy in mice via down-regulating P38 MAPK-mediated inflammation 期刊论文

编号：

c216d47a-bcd9-4ba7-bf05-85a9d61ca638
作者：

Luo, Manyu#^[1,2]Luo, Ping^[1];Zhang, Zhiguo(张志国)^[2,3]Payne, Kristen^[2,4];Watson, Sara^[2,5];Wu, Hao(吴昊)^[1,2]Tan, Yi^[2];Ding, Yushuang^[1];Sun, Weixia(孙伟霞)^[2,3]Yin, Xinmin^[6];Zhang, Xiang^[6];Liu, Gilbert^[2];Wintergerst, Kupper^[2,5];Miao, Lining(苗里宁)*^[1]Cai, Lu(蔡露)*^[2,5]
语种：

英文
期刊：

OBESITY ISSN：1930-7381 2016 年 24 卷 6 期 (1244 - 1256) ; JUN
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摘要：

ObjectiveObesity, particularly child obesity, is one of the most common public health problems in the world and raises the risk of end-stage renal disease. Zinc (Zn) is essential for multiple organs in terms of normal structure and function; however, effects of Zn deficiency or supplementation among young individuals with obesity have not been well studied.
MethodsWeaned mice were fed high-fat diets (HFD) with varied contents of Zn (Zn deficient, adequate, and supplemented) for 3 or 6 months. This study examined associations between renal pathogenesis and dietary Zn levels, specifically assessing inflammatory pathways by utilizing P38 MAPK inhibitor SB203580.
ResultsHFD feeding induced typical syndromes of obesity-related renal disorders, which worsened by Zn marginal deficiency. The progression of obesity-related renal disorders was delayed by Zn supplementation. HFD induced renal inflammation, reflected by increased P38 MAPK phosphorylation along with increases of inflammatory cytokines MCP-1, IL-1, IL-6, and TNF-. P38 MAPK inhibition prevented renal pathological changes in mice fed with HFD and HFD/Zn deficiency.
ConclusionsP38 MAPK mediated the renal inflammatory responses, which played a central role in the pathogenesis of HFD-induced renal disorders. Zn could delay the progression of obesity-related kidney disease by down-regulating P38 MAPK-mediated inflammation.
推荐引用方式
GB/T 7714：

Luo Manyu,Luo Ping,Zhang Zhiguo, et al. Zinc delays the progression of obesity-related glomerulopathy in mice via down-regulating P38 MAPK-mediated inflammation [J].OBESITY,2016,24(6):1244-1256.
APA：

Luo Manyu,Luo Ping,Zhang Zhiguo,Payne Kristen,&Cai Lu.(2016).Zinc delays the progression of obesity-related glomerulopathy in mice via down-regulating P38 MAPK-mediated inflammation .OBESITY,24(6):1244-1256.
MLA：

Luo Manyu, et al. "Zinc delays the progression of obesity-related glomerulopathy in mice via down-regulating P38 MAPK-mediated inflammation" .OBESITY 24,6(2016):1244-1256.
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