Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated, and different cells differentially affect inflammatory reactions after injury. In this review, we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination process. Activated astrocytes influence proliferation, differentiation, and maturation of oligodendrocyte precursor cells, while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord injury. Understanding the interaction between oligodendrocyte precursor cells and the rest of glia is necessary when designing a therapeutic plan of remyelination after spinal cord injury.
[1]Jilin Univ, Hosp 1, Dept Neurosurg, Changchun, Jilin, Peoples R China.
[2]Jilin Univ, Hosp 1, Dept Hepatobiliary & Pancreas Surg, Changchun, Jilin, Peoples R China.
[3]Jilin Univ, Hosp 2, Hand & Foot Surg & Reparat & Reconstruct Surg Ctr, Changchun, Jilin, Peoples R China.
[4]Jilin Univ, Hosp 1, Dept Emergency, Changchun, Jilin, Peoples R China.
[5]Jilin Univ, Hosp 1, Dept Cardiol, Changchun, Jilin, Peoples R China.
[6]Univ Louisville, Sch Med, Dept Surg, Louisville, KY 40292 USA.
[7]Jilin Univ, Hosp 1, Dept Orthoped, Changchun, Jilin, Peoples R China.
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