Brucellosis, a zoonotic disease caused by infection with Brucella melitensis, has a pan-global presence. Neurobrucellosis is a rare complication of the disease. Herein, we presented our experience with a case of neurobrucellosis in a 31-year-old man who presented with a pituitary abscess. Surgical resection of the abscess was performed, and standard combined antibiotic regimen was administered postoperatively. Neurobrucellosis may pose a diagnostic challenge owing to its rarity and the non-specific clinical and radiological findings. Detailed history taking and systematic laboratory examinations of serum and cerebrospinal fluid are keys to an early diagnosis of the condition. Treatment compliance and appropriate surgical intervention are other important aspects of management of neurobrucellosis that confer a favorable prognosis.