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Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma 期刊论文

编号：

cd53a49c-1ec5-47bb-b002-4ff1c8261073
作者：

Zhang, Nan#^[1]Cong, Xiaoqiang(丛晓强)#^[2]Zhou, Dan^[3];Guo, Liang(郭亮)^[4]Yuan, Congwang^[5];Xu, Dahai(徐大海)*^[1]Su, Chang(苏畅)*^[6]
语种：

英文
期刊：

CANCER BIOMARKERS ISSN：1574-0153 2019 年 24 卷 1 期 (7 - 17)
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关键词：

Dipeptidyl peptidase-IV CD26 papillary thyroid carcinoma structurally persistent recurrent disease
摘要：

BACKGROUND: The significance of serum dipeptidyl peptidase-IV (DPP-IV) in papillary thyroid carcinoma (PTC) has not been elucidated.
OBJECTIVE: This study aimed to assess the role of serum DPP-IV in the carcinogenesis and prognosis of PTC.
METHODS: The serum DPP-IV concentration was measured in 171 male patients with PTC, 81 male patients with a benign thyroid nodule (BTN), and 52 male healthy controls (HCs). Multivariate logistic regression and Cox regression analyses were performed to evaluate the correlations between variables. Receiver operating characteristic (ROC) curves were used to calculate the diagnosis accuracy.
RESULTS: The ROC curve indicated a good performance of DPP-IV for discriminating PTC from BTN, with an area under the curve (AUC) of 0.881 (95% CI, 0.840-0.922). Serum DPP-IV demonstrated a modest performance in predicting nonstructurally persistent disease/recurrent disease (NSPRD) survival, with an AUC of 0.778 (95% CI, 0.635-0.922). A serum DPP-IV level >= 250 nkat/L (HR, 6.529; 95% CI, 2.090-20.398; P = 0.001) and an advanced tumor, lymph node, metastasis (TNM) stage (HR, 4.677; 95% CI, 1.498-14.605; P = 0.008) were found to be independent factors for predicting SPRD. PTC patients with a DPP-IV level >= 250 nkat/L had a worse outcome than those with a DPP-IV level < 250 nkat/L (P < 0.001).
CONCLUSIONS: Serum DPP-IV may be a predictive biomarker for PTC diagnosis and prognosis in Chinese male patients.
推荐引用方式
GB/T 7714：

Zhang Nan,Cong Xiaoqiang,Zhou Dan, et al. Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma [J].CANCER BIOMARKERS,2019,24(1):7-17.
APA：

Zhang Nan,Cong Xiaoqiang,Zhou Dan,Guo Liang,&Su Chang.(2019).Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma .CANCER BIOMARKERS,24(1):7-17.
MLA：

Zhang Nan, et al. "Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma" .CANCER BIOMARKERS 24,1(2019):7-17.
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