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Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications 期刊论文

编号：

cebb46e6-131b-4035-b8c6-c55a26a95924
作者：

Liu, Fuyao#^[1,2]He, Xiuxia^[3];Chen, Hongda^[1];Zhang, Junping^[1,3];Zhang, Huimao(张惠茅)*^[4]Wang, Zhenxin(王振新)*^[1]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2015 年 6 卷 ; AUG
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摘要：

An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among Fe3+, gallic acid and poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. The Fe-CPNDs also exhibited pH-activatable magnetic resonance imaging contrast and outstanding photothermal performance. The features of Fe-CPNDs greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. Magnetic resonance imaging-guided photothermal therapy using Fe-CPNDs completely suppressed tumour growth. These findings demonstrate that Fe-CPNDs constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging.
推荐引用方式
GB/T 7714：

Liu Fuyao,He Xiuxia,Chen Hongda, et al. Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications [J].NATURE COMMUNICATIONS,2015,6.
APA：

Liu Fuyao,He Xiuxia,Chen Hongda,Zhang Junping,&Wang Zhenxin.(2015).Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications .NATURE COMMUNICATIONS,6.
MLA：

Liu Fuyao, et al. "Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications" .NATURE COMMUNICATIONS 6(2015).
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