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Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications

  • 编号:
    cebb46e6-131b-4035-b8c6-c55a26a95924
  • 作者:
    Liu, Fuyao(liufuyao)#[1,2] He, Xiuxia[3] Chen, Hongda[1] Zhang, Junping[1,3] Zhang, HuiMao(张惠茅)*[4] Wang, Zhenxin(wangzhenxin)*[1]
  • 语种:
    英文
  • 期刊:
    NATURE COMMUNICATIONS ISSN:2041-1723 2015 年 6 卷 ; AUG
  • 收录:
  • 摘要:

    An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among Fe3+, gallic acid and poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. The Fe-CPNDs also exhibited pH-activatable magnetic resonance imaging contrast and outstanding photothermal performance. The features of Fe-CPNDs greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. Magnetic resonance imaging-guided photothermal therapy using Fe-CPNDs completely suppressed tumour growth. These findings demonstrate that Fe-CPNDs constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging.

  • 推荐引用方式
    GB/T 7714:
    Liu Fuyao,He Xiuxia,Chen Hongda, et al. Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications [J].NATURE COMMUNICATIONS,2015,6.
  • APA:
    Liu Fuyao,He Xiuxia,Chen Hongda,Zhang Junping,&Wang Zhenxin.(2015).Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications .NATURE COMMUNICATIONS,6.
  • MLA:
    Liu Fuyao, et al. "Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications" .NATURE COMMUNICATIONS 6(2015).
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