Wound healing is a complex and sequential process involving various cells and molecules. Chronic non-healing wounds show delayed and incomplete healing processes with significant alteration of the microenvironment of the wound area. In recent years and with the development of nanotechnology, biocompatible nanoparticles capable of delivering bioactive agents in a controlled and sustained manner have emerged as effective strategies and approaches for the treatment of chronic wounds. Biofilm infection represents a major problem for chronic wounds, with consistent characteristics of antibacterial resistance. Metal nanoparticles and nanoparticle-based delivery of antibacterial agents have been developed for controlling biofilm-related infections, and nanocarriers of growth factors and nucleic acids for topical delivery enable balancing of the wound-area microenvironment for tissue regeneration. In this review, we focus on the novel strategies and approaches used for biofilm-infection control and skin-tissue regeneration.
[1]Jilin Univ, Norman Bethune Hosp 1, Changchun 130021, Jilin, Peoples R China.
[2]Jilin Univ, Coll Chem, Alan G MacDiarmid Lab, Changchun 130012, Jilin, Peoples R China.
(8.0+极速模式)