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Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress 期刊论文

编号：

d6315024-a0e7-42ef-ae1e-bfe17325db47
作者：

Liu, XiuFen(刘秀芬)#^[1]Hao, JiLong(郝继龙)^[1]Xie, Tian^[2];Malik, Tayyab Hamid^[3];Lu, ChengBo^[4];Liu, Cong^[1];Shu, Chang(舒畅)^[5]Lu, ChengWei(陆成伟)*^[1]Zhou, DanDan(周丹丹)*^[6]
语种：

英文
期刊：

AGING CELL ISSN：1474-9726 2017 年 16 卷 5 期 (934 - 942) ; OCT
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关键词：

antioxidant response element cataracts Keap1 lenses Nrf2 oxidative stress
摘要：

Cataract is one of the most important causes of blindness worldwide, with age-related cataract being the most common one. Agents preventing cataract formation are urgently required. Substantial evidences point out aggravated oxidative stress as a vital factor for cataract formation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) system is considered as one of the main cellular defense mechanisms against oxidative stresses. This review discusses the role of Nrf2 pathway in the prevention of cataracts and highlights that Nrf2 suppressors may augment oxidative stress of the lens, and Nrf2 inducers may decrease the oxidative stress and prevent the cataract formation. Thus, Nrf2 may serve as a promising therapeutic target for cataract treatment.
推荐引用方式
GB/T 7714：

Liu Xiu-Fen,Hao Ji-Long,Xie Tian, et al. Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress [J].AGING CELL,2017,16(5):934-942.
APA：

Liu Xiu-Fen,Hao Ji-Long,Xie Tian,Malik Tayyab Hamid,&Zhou Dan-Dan.(2017).Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress .AGING CELL,16(5):934-942.
MLA：

Liu Xiu-Fen, et al. "Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress" .AGING CELL 16,5(2017):934-942.
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