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Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant 期刊论文

编号：

da957b84-9452-42ee-a004-142a63efeb44
作者：

Xu, LanPing(许兰平)#^[1]Jin, Song#^[4]Wang, ShunQing(王顺清)#^[5]Xia, LingHui^[6];Bai, Hai^[7];Gao, SuJun(高素君)^[8]Liu, QiFa^[9];Wang, JianMin^[10];Wang, Xin^[11];Jiang, Ming^[12];Zhang, Xi^[13];Wu, DePei(吴德沛)#^[4]Huang, XiaoJun(黄晓军)#*^[1,2,3]
语种：

英文
期刊：

JOURNAL OF HEMATOLOGY & ONCOLOGY ISSN：1756-8722 2017 年 10 卷 ; JAN 21
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关键词：

Upfront Haploidentical transplantation Acquired severe aplastic anemia
摘要：

Background: Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refractory to immunosuppressive therapy (IST). The current study evaluated the feasibility of upfront haploidentical HSCT in SAA patients.
Methods: We conducted a multicenter study based on a registry database. One hundred fifty-eight SAA patients who underwent upfront transplantation between June 2012 and September 2015 were enrolled.
Results: Eighty-nine patients had haploidentical donors (HIDs), and 69 had matched related donors (MRDs) for HSCT. The median times for myeloid engraftment in the HID and MRD cohorts were 12 (range, 9-20) and 11 (range, 8-19) days, with a cumulative incidence of 97.8 and 97.1% (P = 0.528), respectively. HID recipients had an increased cumulative incidence of grades II-IV acute graft-versus-host disease (aGVHD) (30.3 vs. 1.5%, P < 0.001), grades III-IV aGVHD (10.1 vs. 1.5%, P = 0.026), and chronic GVHD (cGVHD) (30.6 vs. 4.4%, P < 0.001) at 1 year but similar extensive cGVHD (3.4 vs. 0%, P = 0.426). The three-year estimated overall survival (OS) rates were 86.1 and 91.3% (P = 0.358), while the three-year estimated failure-free survival (FFS) rates were 85.0 and 89.8% (P = 0.413) in the HID and MRD cohorts, respectively. In multivariate analysis, survival outcome for the entire population was significantly adversely associated with increased transfusions and poor performance status pre-SCT. We did not observe differences in primary engraftment and survival outcomes by donor type.
Conclusions: Haploidentical SCT as upfront therapy was an effective and safe option for SAA patients, with favorable outcomes in experienced centers.
推荐引用方式
GB/T 7714：

Xu Lan-Ping,Jin Song,Wang Shun-Qing, et al. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant [J].JOURNAL OF HEMATOLOGY & ONCOLOGY,2017,10.
APA：

Xu Lan-Ping,Jin Song,Wang Shun-Qing,Xia Ling-Hui,&Huang Xiao-Jun.(2017).Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant .JOURNAL OF HEMATOLOGY & ONCOLOGY,10.
MLA：

Xu Lan-Ping, et al. "Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant" .JOURNAL OF HEMATOLOGY & ONCOLOGY 10(2017).
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