首页 / 院系成果 / 成果详情页

Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy

  • 编号:
    dca54294-a850-44ec-88db-9ef668fe3fcd
  • 作者:
    Zhang, Yan(zhangyan)#[1,2,4] Wang, Faming[1,2,4] Liu, Chaoqun[1,2,4] Wang, Zhenzhen[1,2,4] Kang, LiHua(康丽花)*[3] Huang, Yanyan[1,2,4] Dong, Kai[1,2] Ren, Jinsong(renjinsong)*[1,2] Qu, Xiaogang(quxiaogang)*[1,2]
  • 语种:
    英文
  • 期刊:
    ACS NANO ISSN:1936-0851 2018 年 12 卷 1 期 (651 - 661) ; JAN
  • 收录:
  • 关键词:
  • 摘要:

    Metal-organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of cancers by integrating photosensitizers, which cause cytotoxic effects on cancer, cells by converting tumor oxygen into reactive singlet oxygen (O-1(2)). However, the PDT efficiency of MOFs is severely limited by tumor hypoxia. Herein, by decorating platinum nanozymes on photosensitizer integrated MOFs, we report a simple yet versatile strategy for enhanced PDT. The platinum nanoparticles homogeneously immobilized On MOFs possess high stability and catalase-like activity. Thus, our nanoplatform can facilitate the formation of O-1(2) in hypoxic tumor site via H2O2-activated evolvement of O-2, which can cause more serious damage to cancer cells. Our finding highlights that the composites of nanozymes and MOFs have the potential to serve as efficient agents for cancer therapy, which will open an avenue of nanozymes and MOFs toward biological applications.

  • 推荐引用方式
    GB/T 7714:
    Zhang Yan,Wang Faming,Liu Chaoqun, et al. Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy [J].ACS NANO,2018,12(1):651-661.
  • APA:
    Zhang Yan,Wang Faming,Liu Chaoqun,Wang Zhenzhen,&Qu Xiaogang.(2018).Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy .ACS NANO,12(1):651-661.
  • MLA:
    Zhang Yan, et al. "Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy" .ACS NANO 12,1(2018):651-661.
  • 条目包含文件:
    文件类型:PDF,文件大小:
    正在加载全文
浏览次数:384 下载次数:0
浏览次数:384
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部