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Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function 期刊论文

编号：

de6f85db-fbb3-4676-9223-2e1bc6682e24
作者：

Wang, Yonggang(王永刚)#^[1,2]Zhang, Zhiguo(张志国)^[2,3]Guo, Weiying(郭蔚莹)^[2,3]Sun, Weixia(孙伟霞)^[2,3]Miao, Xiao^[2,4];Wu, Hao(吴昊)^[2,4]Cong, Xianling^[1];Wintergerst, Kupper A.^[5];Kong, Xiangbo(孔祥波)*^[1]Cai, Lu^[2,6,7,8];
语种：

英文
期刊：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM ISSN：0193-1849 2014 年 307 卷 1 期 (E14 - E23) ; JUL 1
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关键词：

male germ cell death sulforaphane nuclear factor (erythroid-derived 2)-like 2 type 2 diabetes high-fat diet
摘要：

Diabetes-induced testicular cell death is due predominantly to oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the antioxidative system and is inducible by sulforaphane (SFN). To test whether SFN prevents diabetes-induced testicular cell death, an insulin-defective stage of type 2 diabetes (IDS-T2DM) was induced in mice. This was accomplished by feeding them a high-fat diet (HFD) for 3 mo to induce insulin resistance and then giving one intraperitoneal injection of streptozotocin to induce hyperglycemia while age-matched control mice were fed a normal diet (ND). IDS-T2DM and ND-fed control mice were then further subdivided into those with or without 4-mo SFN treatment. IDS-T2DM induced significant increases in testicular cell death presumably through receptor and mitochondrial pathways, shown by increased ratio of Bax/Bcl2 expression and cleavage of caspase-3 and caspase-8 without significant change of endoplasmic reticulum stress. Diabetes also significantly increased testicular oxidative damage and inflammation. All of these diabetic effects were significantly prevented by SFN treatment with upregulated Nrf2 expression. These results suggest that IDS-T2DM induces testicular cell death presumably through caspase-8 activation and mitochondria-mediated cell death pathways and also by significantly downregulating testicular Nrf2 expression and function. SFN upregulates testicular Nrf2 expression and its target antioxidant expression, which was associated with significant protection of the testis from IDS-T2DM-induced germ cell death.
推荐引用方式
GB/T 7714：

Wang Yonggang,Zhang Zhiguo,Guo Weiying, et al. Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function [J].AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2014,307(1):E14-E23.
APA：

Wang Yonggang,Zhang Zhiguo,Guo Weiying,Sun Weixia,&Cai Lu.(2014).Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function .AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,307(1):E14-E23.
MLA：

Wang Yonggang, et al. "Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function" .AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307,1(2014):E14-E23.
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