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CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages 期刊论文

编号：

f4e9cc3a-930e-43f3-a4db-f146b76a192d
作者：

Li, Dongling#*^[1,2]Hu, Minling^[1];Liu, Ying^[1];Ye, Peiying^[3,4];Du, Peishuang^[1];Li, ChiShan^[5];Cheng, Liang^[1];Liu, Ping^[1];Jiang, Jing(姜晶)^[6]Su, Lishan^[1,7];Wang, Shengdian^[1];Zheng, Pan^[3,4];Liu, Yang*^[1,2,3,4]
语种：

English
期刊：

CELL DISCOVERY ISSN：2056-5968 2018 年 4 卷 ; FEB 6
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摘要：

It is generally assumed that inflammation following diethylnitrosamine (DEN) treatment promotes development of hepatocellular carcinoma (HCC) through the activity of intrahepatic macrophages. However, the tumor-promoting function of macrophages in the model has not been confirmed by either macrophage depletion or selective gene depletion in macrophages. Here we show that targeted mutation of Cd24 dramatically increased HCC burden while reducing intrahepatic macrophages and DEN-induced hepatocyte apoptosis. Depletion of macrophages also increased HCC burden and reduced hepatocyte apoptosis, thus establishing macrophages as an innate effector recognizing DEN-induced damaged hepatocytes. Mechanistically, Cd24 deficiency increased the levels of p53 in macrophages, resulting in their depletion in Cd24(-/-) mice following DEN treatment. These data demonstrate that the Cd24-p53 axis maintains intrahepatic macrophages, which can remove hepatocytes with DNA damage. Our data establish a critical role for macrophages in suppressing HCC development and call for an appraisal of the current dogma that intrahepatic macrophages promote HCC development.
推荐引用方式
GB/T 7714：

Li Dongling,Hu Minling,Liu Ying, et al. CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages [J].CELL DISCOVERY,2018,4.
APA：

Li Dongling,Hu Minling,Liu Ying,Ye Peiying,&Liu Yang.(2018).CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages .CELL DISCOVERY,4.
MLA：

Li Dongling, et al. "CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages" .CELL DISCOVERY 4(2018).
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