Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer mortality in China. HCC frequently metastasizes to the lungs, abdominal lymph nodes, and skeletal system, but rarely to the gingiva. Here we reported a case of HCC that metastasized to the gingiva. A 60-year-old man with HCC came to our hospital complaining of abdominal distension, jaundice and a gingival mass. The gingival mass was adjacent to the upper incisors and had been bleeding for more than 24 hours. To stop the bleeding, the mass was surgically excised, and an incisional biopsy was performed. Immunohistochemical staining revealed that the tumor cells were positive for hepatocyte paraffin-1, cytokeratins, and glypican-3 and negative for antibody HMB-45, antibody Melan-A, S-100 protein, and a-fetoprotein. Approximately half (51%) of the tumor cells were positive for Ki-67. These observations suggested a histological diagnosis of gingival metastasis of HCC. Two months after surgery, new gingival lesions were observed. The patient refused treatment and died 2 months later. This case indicated that immunohistochemical staining of tumor cells from the gingival mass was necessary to confirm a diagnosis of gingival metastasis of HCC and that this type of HCC metastasis had a very poor prognosis.
[1]Jilin Univ, Hosp 1, Dept Hepatol, 71 Xinmin St, Changchun, Jilin Province, Peoples R China.
(8.0+极速模式)