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Lkb1 maintains T-reg cell lineage identity 期刊论文

编号：

f7180f66-4882-4a1a-9173-5aac870e8e7f
作者：

Wu, Di#^[1,2,3]Luo, Yuechen#^[1,2,3]Guo, Wei#^[1,2,3]Niu, Qing^[1,2,3];Xue, Ting^[4];Yang, Fei^[1,2,3];Sun, Xiaolei^[1,2,3];Chen, Song^[1,2,3];Liu, Yuanyuan^[1,2,3];Liu, Jingru^[5];Sun, Zhina^[1,2,3];Zhao, Chunxiao^[1,2,3];Huang, Huifang^[5];Liao, Fang^[4];Han, Zhongchao^[1,2,3];Zhou, Dongming^[6];Yang, Yongguang(杨永广)^[7]Xu, Guogang^[8];Cheng, Tao(程涛)*^[1,2,3]Feng, Xiaoming(冯晓明)*^[1,2,3]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2017 年 8 卷 ; JUN 16
收录：
摘要：

Regulatory T (T-reg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve T-reg lineage-specific features are mostly unknown. Here, we show that Lkb1 maintains T-reg cell lineage identity by stabilizing Foxp3 expression and enforcing suppressor function. Upon T-cell receptor (TCR) stimulation Lkb1 protein expression is upregulated in T-reg cells but not in conventional T cells. Mice with T-reg cell-specific deletion of Lkb1 develop a fatal early-onset autoimmune disease, with no Foxp3 expression in most T-reg cells. Lkb1 stabilizes Foxp3 expression by preventing STAT4-mediated methylation of the conserved noncoding sequence 2 (CNS2) in the Foxp3 locus. Independent of maintaining Foxp3 expression, Lkb1 programs the expression of a wide spectrum of immunosuppressive genes, through mechanisms involving the augmentation of TGF-beta signalling. These findings identify a critical function of Lkb1 in maintaining T-reg cell lineage identity.
推荐引用方式
GB/T 7714：

Wu Di,Luo Yuechen,Guo Wei, et al. Lkb1 maintains T-reg cell lineage identity [J].NATURE COMMUNICATIONS,2017,8.
APA：

Wu Di,Luo Yuechen,Guo Wei,Niu Qing,&Feng Xiaoming.(2017).Lkb1 maintains T-reg cell lineage identity .NATURE COMMUNICATIONS,8.
MLA：

Wu Di, et al. "Lkb1 maintains T-reg cell lineage identity" .NATURE COMMUNICATIONS 8(2017).
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