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Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation 期刊论文

编号：

f74627c8-c203-4dff-a8c6-f4d68cc46b17
作者：

Schaefer, Jan Hendrik#*^[1,2]Leung, Wendy^[2];Wu, Limin^[2,3];Van Cott, Elizabeth M.^[4];Lok, Josephine^[2,5];Whalen, Michael^[5,6];van Leyen, Klaus^[2];Lauer, Arne^[1];van Ryn, Joanne^[7];Lo, Eng H.^[2];Foerch, Christian^[1];
语种：

英文
期刊：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM ISSN：0271-678X 2014 年 34 卷 5 期 (870 - 875) ; MAY
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关键词：

anticoagulation dabigatran intracerebral hemorrhage novel oral anticoagulants traumatic brain injury warfarin
摘要：

To date, only limited data are available on the effects of pretreatment with novel oral anticoagulants in the event of traumatic brain injury (TBI). We determined intracerebral hemorrhage volume and functional outcome in a standardized TBI model in mice treated with warfarin or dabigatran. Additionally, we investigated whether excess concentrations of dabigatran could increase bleeding and whether this was preventable by using prothrombin complex concentrate (PCC). C57 mice were treated orally with warfarin or dabigatran; sham-treated mice served as controls. Effective anticoagulation was verified by measurement of international normalized ratio and diluted thrombin time, and TBI was induced by controlled cortical impact (CCI). Twenty-four hours after CCI, intracerebral hemorrhage volume was larger in warfarin-pretreated mice than in controls (10.1 +/- 4.9 vs 4.1 +/- 1.7 mu L; analysis of variance post hoc P=0.001), but no difference was found between controls and dabigatran-pretreated mice (5.3 +/- 1.5 mu L). PCC applied 30 minutes after CCI did not reliably reduce intracerebral hemorrhage induced by excess dabigatran concentration compared with saline (10.4 +/- 11.2 vs 8.7 +/- 7.1 mu L). Our data suggest pathophysiological differences in TBI occurring during warfarin and dabigatran anticoagulation. The reduced hemorrhage formation under dabigatran therapy could present a safety advantage compared with warfarin. An excess dabigatran concentration, however, can increase hemorrhage.
推荐引用方式
GB/T 7714：

Schaefer Jan Hendrik,Leung Wendy,Wu Limin, et al. Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation [J].JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2014,34(5):870-875.
APA：

Schaefer Jan Hendrik,Leung Wendy,Wu Limin,Van Cott Elizabeth M.,&Foerch Christian.(2014).Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation .JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,34(5):870-875.
MLA：

Schaefer Jan Hendrik, et al. "Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation" .JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 34,5(2014):870-875.
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