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Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1 期刊论文

编号：

f91082e9-6c3c-441a-a947-e8c3ffe3abf9
作者：

Cheng, Yingying(程莹莹)#^[1,2]Xi, Guohua^[1];Jin, Hang(靳航)^[1,2]Keep, Richard F.^[1];Feng, Jiachun(冯加纯)^[2]Hua, Ya*^[1]
语种：

英文
期刊：

TRANSLATIONAL STROKE RESEARCH ISSN：1868-4483 2014 年 5 卷 4 期 (472 - 475) ; AUG
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关键词：

Cerebral hemorrhage Interleukin-1 beta Protease-activated receptor-1 (PAR-1) Thrombin
摘要：

Thrombin causes blood-brain barrier disruption, and this study examined whether thrombin can cause brain hemorrhage through protease-activated receptor-1 (PAR-1). Male wild type and PAR-1 knockout mice had an intracerebral injection of thrombin or saline. Mice then underwent serial T2 magnetic resonance imaging and were euthanized for brain hemoglobin, iron, and interleukin-1 beta measurements. Thrombin caused massive T2 lesions and brain hemorrhage in wild type mice. These effects were markedly reduced in PAR-1 knockout mice. Thrombin also increased brain interleukin-1 beta, and this was absent in PAR-1 knockout mice. In conclusion, thrombin increases interleukin-1 beta levels and induces intracerebral hemorrhage through PAR-1 activation.
推荐引用方式
GB/T 7714：

Cheng Yingying,Xi Guohua,Jin Hang, et al. Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1 [J].TRANSLATIONAL STROKE RESEARCH,2014,5(4):472-475.
APA：

Cheng Yingying,Xi Guohua,Jin Hang,Keep Richard F.,&Hua Ya.(2014).Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1 .TRANSLATIONAL STROKE RESEARCH,5(4):472-475.
MLA：

Cheng Yingying, et al. "Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1" .TRANSLATIONAL STROKE RESEARCH 5,4(2014):472-475.
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