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Diagnostic accuracy of F-18-fluorodeoxyglucose positron emission tomography/computed tomography in differentiated thyroid cancer patients with elevated thyroglobulin and negative I-131 whole body scan: evaluation by thyroglobulin level 期刊论文

编号：

fceb2c5a-461a-4c33-acfd-547d0400c89e
作者：

Na, Sae Jung#^[2]Yoo, Ie Ryung*^[1,2]O, Joo Hyun^[2];Lin, Chenghe(林承赫)^[3]Lin, Qiuyu(林秋玉)^[3]Kim, Sung Hoon^[2];Chung, Soo Kyo^[2];
语种：

英文
期刊：

ANNALS OF NUCLEAR MEDICINE ISSN：0914-7187 2012 年 26 卷 1 期 (26 - 34) ; JAN
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关键词：

Thyroid cancer F-18-FDG PET/CT Thyroglobulin Radioiodine imaging
摘要：

Background To evaluate the diagnostic accuracy of F-18-FDG PET/CT in detection of recurrent differentiated thyroid cancer (DTC) in patients with elevated stimulated thyroglobulin (Tg) or anti-Tg antibody (Ab) levels, and negative I-131 whole body scan according to the Tg level.
Methods PET/CT images of well DTC patients who had total thyroidectomy and radioiodine ablation were included. Patients showing elevated Tg titer (>= 2.0 ng/ml after TSH stimulation) or elevated anti-Tg titer (>= 70.0 IU/ml) while diagnostic radioiodine scan was negative were enrolled. PET/CT was classified as positive or negative on the basis of visual interpretation. The maximum standard uptake values (SUVmax) of the suspected lesions on PET/CT were also recorded. The PET/CT findings were compared with histological or clinical follow-up results based on other imaging modalities and serum Tg/anti-Tg Ab titers. The diagnostic performance of PET/CT was compared among 4 subgroups according to the Tg level [2 ng/ml <= stimulated Tg (sTg) < 5 ng/ml, 5 ng/ml <= sTg < 10 ng/ml, 10 ng/ml <= sTg < 20 ng/ml, and >= 20 ng/ml].
Results A total of 68 PET/CT images from 60 patients were included, and histological confirmations were available in 32 images. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT were 69.4, 66.7, 69.1, 95.6, and 17.4%, respectively. There were 3 PET/CT cases with high anti-Tg Ab level, and low (<2 ng/ml) Tg level, and all 3 were positive of recurrence. The mean SUVmax of the suspected lesions on PET/CT was 2.9 +/- 4.5 (range 1.3-29.7). The sensitivity of PET/CT according to Tg levels was 28.6% when Tg was between 2 and 5, 57.1% between 5 and 10, 60.0% between 10 and 20, and 85.7% when Tg was equal to or greater than 20 ng/ml sub-groups, respectively.
Conclusion Diagnostic accuracy of FDG PET in radioiodine negative thyroid cancer may vary depending on serum Tg levels at imaging. F-18-FDG PET/CT is useful in detection and localization of recurrent thyroid cancer in patients with negative diagnostic radioiodine scan despite elevated Tg greater than 20 ng/ml or high anti-Tg Ab titers. In contrast, PET/CT provides little additional information when the Tg is less than 5 ng/ml.
推荐引用方式
GB/T 7714：

Na Sae Jung,Yoo Ie Ryung,O Joo Hyun, et al. Diagnostic accuracy of F-18-fluorodeoxyglucose positron emission tomography/computed tomography in differentiated thyroid cancer patients with elevated thyroglobulin and negative I-131 whole body scan: evaluation by thyroglobulin level [J].ANNALS OF NUCLEAR MEDICINE,2012,26(1):26-34.
APA：

Na Sae Jung,Yoo Ie Ryung,O Joo Hyun,Lin Chenghe,&Chung Soo Kyo.(2012).Diagnostic accuracy of F-18-fluorodeoxyglucose positron emission tomography/computed tomography in differentiated thyroid cancer patients with elevated thyroglobulin and negative I-131 whole body scan: evaluation by thyroglobulin level .ANNALS OF NUCLEAR MEDICINE,26(1):26-34.
MLA：

Na Sae Jung, et al. "Diagnostic accuracy of F-18-fluorodeoxyglucose positron emission tomography/computed tomography in differentiated thyroid cancer patients with elevated thyroglobulin and negative I-131 whole body scan: evaluation by thyroglobulin level" .ANNALS OF NUCLEAR MEDICINE 26,1(2012):26-34.
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