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A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population 期刊论文

编号：

fe7d59bf-7344-49f7-a690-7886870ca6a4
作者：

Qin, Ling(秦玲)#^[2]Sun, Lin#^[1]Ye, Lin^[1];Shi, Jieping^[1];Zhou, Liting^[1];Yang, Jingyu^[1];Du, Bing(杜冰)^[2]Song, Zikai(宋子凯)^[2]Yu, Yaqin^[1];Xie, Lin(谢林)*^[1]
语种：

English
期刊：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS ISSN：0952-3278 2011 年 85 卷 6 期 (329 - 333) ; DEC
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关键词：

FADS1 FADS2 ELOVL2 CAD Gene variants
摘要：

To investigate the association between the polymorphisms of fatty acid clesaturase 1 (FADS1), fatty acid desaturase 2 (FADS2) and elongation of very long chain fatty acids like 2 (ELOVL2) gene and coronary artery disease (CAD) in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) from these genes were genotyped using PCR-based restriction fragment length polymorphism analysis in 199 CAD cases and 192 controls of Han Chinese origin. rs174556 in the FADS1 gene showed allelic (P=0.002) and genotypic (P=0.030) association with the disease, while there was no disease association for the other two SNPs. The frequency of rs174556 minor allele (T) was significantly higher in the case group than the control group. The trans phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was weakly associated with the disease (P=0.043). rs174556 in the FADS1 gene is very likely to be associated with CAD in the Chinese Han population. (C) 2011 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Qin Ling,Sun Lin,Ye Lin, et al. A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population [J].PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS,2011,85(6):329-333.
APA：

Qin Ling,Sun Lin,Ye Lin,Shi Jieping,&Xie Lin.(2011).A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population .PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS,85(6):329-333.
MLA：

Qin Ling, et al. "A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population" .PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 85,6(2011):329-333.
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