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Pharmacological targeting of AMPK to restore glucose and fatty acid metabolism homeostasis attenuates transplanted kidney fibrosis  期刊论文  

  • 编号:
    2F00381F4A14ADF68A00BDC0F8664564
  • 作者:
    Liu, Bin#[1]Zhang, Yanghe[1];Wang, Yuxiong[1];Meng, Qingfei[2];Zhang, Dan[2];Yang, Hongxia[2];Li, Guangtao[2];Wang, Yishu*[2]Zhou, Honglan(周洪澜)*[1]
  • 语种:
    英文
  • 期刊:
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE ISSN:0925-4439 2025 年 1871 卷 1 期 ; JAN
  • 收录:
  • 关键词:
  • 摘要:

    Chronic fibrosis often occurs in transplanted kidneys, leading to progressive functional decline. The underlying mechanisms may involve disruption in the metabolism of renal tubular epithelial cells. The liver kinase B1 (LKB1)-AMPK pathway is a pivotal regulatory hub for glucose and fatty acid metabolism and may play a role in transplanted kidney fibrosis, but it has not been reported. In this study we administered fenofibrate, 2-deoxyglucose, or metformin to modulate metabolism in Brown Norway rat kidney transplants and investigated pathways involved in fibrosis using various assays. We identified an impaired LKB1-AMPK pathway within epithelial cells, resulting in perturbed glucose and fatty acid metabolism, collagen secretion, extracellular matrix remodeling, and epithelial-mesenchymal transition. ACOX1, a pivotal enzyme in the fatty acid peroxisomal beta-oxidation pathway, played an important role in transplanted renal fibrosis. Furthermore, several metabolism-targeting drugs, particularly metformin, emerged as potent fibrosis inhibitors. Metformin attenuated fibrosis, improved renal function, and reduced inflammation and macrophage infiltration in the transplanted kidneys. These results provide new perspectives for understanding the complex molecular basis underlying transplanted renal fibrosis and developing novel therapeutic strategies.

  • 推荐引用方式
    GB/T 7714:
    Liu Bin,Zhang Yanghe,Wang Yuxiong, et al. Pharmacological targeting of AMPK to restore glucose and fatty acid metabolism homeostasis attenuates transplanted kidney fibrosis [J].BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2025,1871(1).
  • APA:
    Liu Bin,Zhang Yanghe,Wang Yuxiong,Meng Qingfei,&Zhou Honglan.(2025).Pharmacological targeting of AMPK to restore glucose and fatty acid metabolism homeostasis attenuates transplanted kidney fibrosis .BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1871(1).
  • MLA:
    Liu Bin, et al. "Pharmacological targeting of AMPK to restore glucose and fatty acid metabolism homeostasis attenuates transplanted kidney fibrosis" .BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1871,1(2025).
  • 入库时间:
    10/8/2024 9:25:28 PM
  • 更新时间:
    10/23/2024 6:07:31 AM
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